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Journal of Medicinal Plants and By-products، جلد ۱۴، شماره ۲، صفحات ۱۱۲-۱۲۰
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عنوان انگلیسی The Phytochemical Content and Cytotoxic Effects of Quinoa Commercial Cultivars (Chenopodium quinoa Willd.) on MCF7 Cell Line of Breast Cancer
چکیده انگلیسی مقاله The Black, Titicaca, and Multi-hued Bulk cultivars were cultivated in the arid and semi-arid regions of Iran to compare the phenolic compounds, antioxidant, and cytotoxic effects of seed and leave extracts of Quinoa on the MCF7 cell line of breast cancer (at 100, 250, 500, and 1000 mg/ml concentrations). The bioactive compounds of samples were extracted using the hydroethanolic solvent using the Soxhlet method. According to this research, although the Titicaca seed extract had the highest total phenolic content at 1000 mg/ml (152 mg GAE/g), the highest average phenolic content was observed in the leaf extracts of all cultivars. So, the seed extract of the Black cultivar showed the highest flavonoid content at 1000 mg/ml (268 mg QE/g DW). The most increased DPPH radical scavenging activity was observed in the leaf extract of the Black cultivar (54.23%), and the highest ferric-reducing power was exhibited by Titicaca leaf extract at 1000 mg/ml (0.37 mmol Fe2+). The results indicated that the leaf extract of the Black cultivar had the lowest IC50 value (786.95 mg/ml). Based on the results, the leaf and seed extracts of Black and Titicaca cultivars were selected to examine the cytotoxic effects of Quinoa extracts on the MCF7 cell line due to their higher phenolic and antioxidant contents. The lowest MCF7 cell line viability percentage (13.92%) was observed in the leaf extract of the Black cultivar at 1000 mg/ml concentration after 72 hours. Regardless of the extract concentration, the leaf and Black cultivar were the superior organ and cultivar compared to other studied characteristics, respectively. In addition, 72 hours significantly yielded better results than other periods.
کلیدواژه‌های انگلیسی مقاله Black Quinoa,DPPH,MCF7 Cell Line,MTT assay
نویسندگان مقاله S. Ebrahim Seifati |
Department of Arid Land and Desert Management, School of Natural Resources and Desert Studies, Yazd University, Yazd, Iran

Mohamad Reza Ranaiezadeh |
Department of Arid Land and Desert Management, School of Natural Resources and Desert Studies, Yazd University, Yazd, Iran

Fatemeh Daneshmand |
Biology Department, Payame Noor University, Tehran, Iran

Zahra Karimi Bekr |
Department of Horticulture, Faculty of Agriculture, Shahed University, Tehran, Iran

Mohammad-Bagher Rezaee |
Department of Medicinal Plants, Research Institute of Forest and Rangelands, Tehran, Iran

نشانی اینترنتی https://jmpb.areeo.ac.ir/article_130801_cf10b986bc360ad2c6ffd386e13ca318.pdf
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