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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۶، صفحات ۷۱۸-۷۲۷
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عنوان انگلیسی Can resisted swimming exercise substitute for the protective effects of estrogen on cardiometabolic risk factors in obese postmenopausal rat model?
چکیده انگلیسی مقاله Objective(s): Following our previous studies on the anti-obesity and cardioprotective effects of 17-beta estradiol (E2), this study was designed to determine the effects of Resisted swimming (RSW) training and E2 (alone and in combination) on cardiometabolic risk factors in an obese postmenopausal rat model.Materials and Methods: Female ovariectomized rats (OVX) were given a standard diet (SD) or a 60% high-fat diet (HFD) for 16 weeks and were divided into two groups:  SD and HFD. The rats were divided into ten groups to assess the effects of 8 weeks of E2 (1 mg/kg, IP) administration and RSW (5 days a week) on cardiometabolic risk factors. Parameters including body weight, BMI, visceral fat, blood glucose (BG), and cardiac oxidative stress were assessed 72 hr after the last swimming session.Results: HFD increased body weight, BMI, visceral fat, and BG levels in OVX rats. Additionally, it negatively affected the lipid profile and cardiac oxidative stress, but both E2 and RSW reduced these parameters in HFD-fed OVX rats. Although RSW and E2 equally prevented these changes, swimming was more effective than estrogen in increasing HDL levels in the SD group. The combination of E2 and RSW had a more significant effect on modulating glucose, TAC, TG, and HDL indices than the individual treatments.  Conclusion: Overall, RSW ameliorates cardiometabolic risk factors in postmenopausal conditions caused by obesity, probably by modulating cardiac oxidative stress. It is also an effective non-pharmacological treatment for E2 substitution. 
کلیدواژه‌های انگلیسی مقاله 17 beta-estradiol, Bilateral ovariectomies, High-fat diet, Oxidative stress, Swimming
نویسندگان مقاله | Sara Shirazpour
Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences,Kerman, Iran


| Mohammad Khaksari
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran


| Abbas Ali Gaeini
Department of Exercise Physiology, University of Tehran, Tehran, Iran


| Hamideh Bashiri
Institute of Neuropharmacology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran


| Kayvan Khoramipour
Department of Physiology, Faculty of Medicine, Kerman University of Medical Sciences,Kerman, Iran|i+HeALTH Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), 47012 Valladolid, Spain


| Forouzan Rafie
Institute of Neuropharmacology, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran|Emory University School of Medicine Division of Geriatrics and Gerontology, Atlanta, Georgia, USA
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25621.html
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