این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۶، صفحات ۷۳۹-۷۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects and mechanism of puerarin on lactation of postpartum hypogalactia mice
چکیده انگلیسی مقاله Objective(s): Insufficient breast milk supply is a common reason cited for discontinuing breastfeeding prematurely. Natural galactagogues offer promise as a solution for mothers with low milk production. This study aimed to explore puerarin’s potential effects and underlying mechanism on lactation of postpartum hypogalactia mice.Materials and Methods: Postpartum mice were randomly assigned to five groups: control group, agalactosis model group, domperidone group (3.5 mg/kg), low dose puerarin group (18 mg/kg), and high dose puerarin group (72 mg/kg). The effects of puerarin on postpartum hypogalactia mice were evaluated by lactation indicators and pathological morphology. Related hormones and prolactin receptor (PRLR)/Janus kinase 2 (JAK2)/signal transduction and activator (STAT) 5 signaling pathway were also measured.Results: Puerarin significantly improved lactation yield and stimulated mammary gland development in postpartum hypogalactia mice. Additionally, puerarin increased the expression levels of β-casein, fatty acid synthase (FAS), and glucose transporter 1 (GLUT1). Mechanically, puerarin stimulated secretion of prolactin (PRL), estradiol (E2), and progesterone (P4) in agalactosis mice. Puerarin also substantially increased PRLR, JAK2, and STAT5a expression levels in postpartum hypogalactia mice. Conclusion: This study suggested that puerarin may promote lactation by stimulating PRL secretion and activating the PRLR/JAK2/STAT5 signaling pathway.
کلیدواژه‌های انگلیسی مقاله Breast Feeding, Domperidone, Galactogogues, Phytoestrogens, Prolactin
نویسندگان مقاله | Ya-jie Yang
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China


| Bing-qing Liu
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China


| Yang Jiang
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China


| Man-yu Zhou
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China


| Re-yi-la Tuerxun
Traditional Chinese Medicine Hospital of Xinjiang Uyghur Autonomous Region, Xinjiang, 830092, China


| Hong-shuang Liu
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China


| Yan Liao
School of Chinese Medical, Beijing University of Chinese Medicine, Beijing, 102446, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25622.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات