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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۶، صفحات ۷۹۰-۷۹۸
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عنوان انگلیسی Adropin exerts neuroprotection in an experimental rat model of Parkinson’s disease
چکیده انگلیسی مقاله Objective(s): This study was planned to elucidate the mechanism of the protective effect of adropin in an experimental rat model of Parkinson’s Disease (PD). Materials and Methods: Three-month-old male Wistar rats were randomly divided into four groups: i) Control, ii) Sham, iii) PD, and iv) PD+Adropin. The performance tests were performed seven days after the 6-Hydroxydopamine hydrochloride (6-OHDA) injection into the striatum. The immunoreactivities for tyrosine hydroxylase (TH), G protein-coupled receptor 19 (GPR19), and vascular endothelial growth factor receptor 2 (VEGFR2) were detected by immunohistochemistry (IHC) in the substantia nigra (SN). Dopamine levels were measured by mass spectrometry. Glycogen synthase kinase 3β (GSK‑3β) and p‑GSK‑3β (Ser9) protein levels were evaluated by western blot analysis. Results: Our study demonstrated that motor performances were significantly improved by adropin treatment. Central adropin injection prevented the loss of nigral dopaminergic neurons and induced VEGFR2 expression but not GPR19 compared to the PD group. The ratio of p-GSK3β/GSK3β did not differ between groups. However, the level of dopamine in SN was increased with adropin injection in the PD+Adropin group. Conclusion: Our findings reveal that adropin administration has a protective effect on nigral dopaminergic neurons and acts through the VEGFR2 signaling pathway.
کلیدواژه‌های انگلیسی مقاله Adropin, Dopamine, GPR19, Parkinson’s disease, VEGFR2
نویسندگان مقاله | Ayse Ozkan
Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey|Department of Physiology, Izmir Bakırçay University, Faculty of Medicine, İzmir, Turkey


| Hande Parlak
Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey|Department of Physiology, Amasya University, Faculty of Medicine, Amasya, Turkey


| Osman Sinen
Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey


| Mehmet Bulbul
Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey


| Mutay Aydin Aslan
Department of Medical Biochemistry, Faculty of Medicine, Antalya, Turkey


| Aysel Ağar
Department of Physiology, Akdeniz University, Faculty of Medicine, Antalya, Turkey
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25745.html
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