| چکیده انگلیسی مقاله |
The Pediatric Buccal Epigenetic (PedBE) and Neonatal Epigenetic Estimator of Age (NEOage) clocks provide a novel method for assessing the biological age of young individuals, enhancing our comprehension of their health and development. By analyzing DNA methylation patterns, these clocks identify risk factors for various health conditions and guide personalized interventions to promote optimal growth in children and infants. With ongoing research and validation, PedBE and NEOage could revolutionize pediatric and neonatal healthcare by facilitating early detection of age-related changes and targeted interventions to improve long-term outcomes. In pediatric oncology, PedBE is particularly promising for evaluating biological age in children with cancer, as it accurately estimates DNA methylation age in buccal cells, revealing the effects of cancer and its treatments on biological aging. Additionally, PedBE can detect DNA methylation changes associated with environmental exposures and childhood adversities, making it a valuable tool for studying the impact of cancer on the epigenetic age of pediatric patients. The NEOage clock, designed to predict gestational age in newborns, complements the PedBE clock, offering a comprehensive assessment of biological age from infancy to adolescence, which is vital for understanding pediatric oncology’s influence on aging. This paper examines the complexities of both clocks, highlighting their potential for accurately determining the age of children and infants through DNA methylation analysis. |
| نویسندگان مقاله |
| Amirhossein Omidi
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Maryam Sadat Yazdanparast
Hematology and Oncology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Seyedeh Elham Shams
Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
| Reza Bahrami
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
| Mohammad Golshan-Tafti
Department of Pediatrics, Islamic Azad University of Yazd, Yazd, Iran
| Seyed Alireza Dastgheib
Department of Medical Genetics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Maryam Yeganegi
Department of Obstetrics and Gynecology, Iranshahr University of Medical Sciences, Iranshahr, Iran
| Mahsa Danaie
Department of Obstetrics and Gynecology, Iran University of Medical Sciences, Tehran, Iran
| Ali Masoudi
Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Amirmasoud Shiri
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Maryam Aghasipour
Department of Cancer Biology, College of Medicine, University of Cincinnati, Ohio, USA
| Kazem Aghili
Department of Radiology, Shahid Rahnamoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Mahmood Noorishadkam
Department of Radiology, Shahid Rahnamoun Hospital, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
| Hossein Neamatzadeh
Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
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