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Iranian Journal of Veterinary Science and Technology، جلد ۱۷، شماره ۱، صفحات ۴۵-۵۴
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عنوان انگلیسی Effects of Vernonia amygdalina Extract on the Modulation of Liver Antioxidant Enzymes, Cytokines, Adipokines, DNA Biomarkers, and Growth in Aflatoxin B1-Exposed Broiler Chickens
چکیده انگلیسی مقاله Aflatoxicosis has emerged as a notable factor that hampers the well-being and productivity of broilers in recent times. This study examined V. amygdalina leaf extract's protective effects against aflatoxin B1-induced hepatoxicity and growth suppression in broiler chickens. 240 Cobb500 day-old chicks were divided into 4 groups: CONT (uncontaminated diet), AFTB1 (0.5 ppm aflatoxin B1 contamination), VE1AF (0.5 ppm aflatoxin B1 + 1 g V. amygdalina leaf powder/liter of water), and VE2AF (0.5 ppm aflatoxin B1 + 2 g V. amygdalina leaf powder/liter of water) in a completely randomized design. Liver catalase, glutathione peroxidase, and superoxide dismutase levels exhibited a marked reduction in the AFTB1 group compared to CONT and VE2AF groups (p < 0.05). Malondialdehyde levels, indicative of lipid peroxidation, were markedly increased in the AFTB1 group compared to all other groups (p < 0.05). The levels of pro-inflammatory cytokines (TNF-α, IL-6, and IFN-γ) exhibited a marked increase in the AFTB1 group compared to CONT and VE2AF groups (p < 0.05). Additionally, anti-inflammatory cytokines, adipokines, and oxidative DNA damage biomarkers varied significantly among treatment groups (p < 0.05). Both 1 g and 2 g of V. amygdalina leaf powder per liter of water effectively countered the detrimental effects of aflatoxin B1 on liver health in broiler chickens.
کلیدواژه‌های انگلیسی مقاله Aflatoxicosis,Hepatoxicity mitigation,Phytochemicals,poultry
نویسندگان مقاله Olugbenga David Oloruntola |
Animal Science Department, Adekunle Ajasin University, Akungba Akoko, Nigeria.

Samuel Adebowale Adeyeye |
Department of Animal Production and Health, The Federal College of Agriculture, Akure, Nigeria.

Fehintoluwa Stellamaris Oluwaniyi |
Animal Science Department, Adekunle Ajasin University, Akungba Akoko, Nigeria.

Olumuyiwa Joseph Olarotimi |
Department of Medical Laboratory Science, University of Medical Sciences, Ondo City, Nigeria.

Deborah Adebukola Oloruntola |
Department of Medical Laboratory Science, University of Medical Sciences, Ondo City, Nigeria

Emmanuel Kehinde Asaniyan |
Department of Animal Production and Health, Olusegun Agagu University of Science and Technology, Okiti Pupa, Nigeria.

Ojurereoluwa Adebimpe Ayodele |
Animal Science Department, Adekunle Ajasin University, Akungba Akoko, Nigeria.

Olufemi Emmanuel Adeniji |
Animal Science Department, Adekunle Ajasin University, Akungba Akoko, Nigeria.

نشانی اینترنتی https://ijvst.um.ac.ir/article_46435_d9d66e74d270f000715535da7e69cae8.pdf
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