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Analytical and Bioanalytical Chemistry Research، جلد ۱۲، شماره ۳، صفحات ۲۸۱-۲۹۱
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عنوان انگلیسی A Novel Single-channel Continuous Flow Injection Spectrophotometry Determination of Nalidixic Acid through Oxidative Coupling Reaction
چکیده انگلیسی مقاله In this study, a novel sensitive and selective method was developed for the determination of nalidixic acid (NAL). The method utilizes 4-aminoantipyrine (4-AAP) as a coupling agent in an oxidative coupling reaction with NAL. The reaction between NAL and 4-AAP, in the presence of potassium periodate (KIO₄) as oxidizing agent, produced a pink-violet colored product with a maximum absorption wavelength at 530 nm. The linear calibration curve for the determination of NAL by developed continuous flow injection analysis/ merging zones technique (CFIA/MZT) method ranged from 5 to 400 µg mL⁻¹. The limit of detection (LOD) and limit of quantification (LOQ) of the method were obtained as 1.90 µg mL⁻¹ and 6.34 µg mL⁻¹, respectively. The method demonstrated excellent precision, with a relative standard deviation (RSD%) of 0.49%. The sampling rate achieved was 80 samples per hour. The developed CFIA/MZT method was validated and compared with the official titration method outlined in the United States Pharmacopoeia (USP), showing favorable agreement.
کلیدواژه‌های انگلیسی مقاله continuous flow injection analysis,Nalidixic acid,4-Aminoantipyrine,pharmaceutics
نویسندگان مقاله Bushra B Qassim |
Department of Chemistry, College of Science, University of Baghdad, Iraq.

Hashim J Abdullah |
National Center of Hematology, Mustansiriyah University, Baghdad, Iraq.

نشانی اینترنتی https://www.analchemres.org/article_217837_591c12123e93b3a72b8bcc2d61e9e72d.pdf
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