این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Cell Journal، جلد ۲۶، شماره ۱۱، صفحات ۶۳۲-۳۴۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Diagnosis Prostate Cancer via Molecular Computed Tomography Imaging based on Targeted Gold Nanoparticles
چکیده انگلیسی مقاله Objective: Nanocomplexes, as targeted contrast agents, have been developing for diagnostic imaging, especially in computed tomography (CT). The present study aimed to investigate a novel approach using Triptorelin-conjugated-coated Gold Nanoparticles (TAuNPs) for early prostate cancer diagnosis through molecular CT imaging.
Materials and Methods: In the current experimental study, AuNPs and TAuNPs were synthesized and then characterized using transmission electron microscopy (TEM), fourier transform infrared (FTIR) spectroscopy, and dynamic light scattering (DLS), and the AuNPs cytotoxicity and the cell viability were also assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay. The intensity of X-ray attenuation and contrast to noise ratio (CNR) for nontargeted and targeted nanoparticles were measured for tube voltages of 90.0, 120.0, and 140.0 kVp at different mAs, and the four different concentrations, including 25.0, 50.0, 75.0, and 100.0 μg/ml.
Results: The synthesized TAuNPs are non-toxic within the concentration range of 25-100 μg/ml, at tube potentials of 90.0, 120.0, and 140.0 kVp, and 145.0 as well as 266.0 mA. Also, the X-ray attenuation of targeted cells was 1.74, 2.23, and 2 times higher, respectively, than that of non-targeted cells for a concentration of 100 μg/ml. Furthermore, the CNR values for TAuNPs compared to AuNPs at tube potentials of 90.0, 120.0, and 140.0 kVp, and 266.0 mA, were 1.65, 3.35, and 2.57 c/ϭ, respectively.
Conclusion: The current study demonstrates that synthesized TAuNPs are emerged as a contrast agent, which is targeted for molecular CT imaging of prostate cancer cells, expressing the gonadotropin-releasing hormone (GnRH) receptor.
کلیدواژه‌های انگلیسی مقاله Contrast agents,Molecular imaging,prostate cancer,Targeted imaging,Triptorelin
نویسندگان مقاله Farzaneh Ghorbani |
Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Samaneh Abbasi |
Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Fatemeh Rabani |
Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Sara Khademi |
Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

Alireza Montazerabadi |
Department of Medical Physics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://www.celljournal.org/article_721599_f3e7335c7bbaec4be37850e5549ec77e.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات