| چکیده انگلیسی مقاله |
Introduction: The primary aim of this study was to evaluate the association of metabolic syndrome (MetS), based on different definitions, with the risk of total cardiovascular disease (CVD), unstable angina (UA), stable angina (SA), and myocardial infarction (MI). Additionally, we aimed to investigate which definition of MetS is a better predictor of CVD events in a large sample of Iranian adults.Methods: The analysis was conducted among 7,910 adults from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The presence of MetS at baseline was defined using the following criteria: International Diabetes Federation (IDF 2005), National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), and World Health Organization (WHO). Hazard ratios (HR) and 95% confidence intervals (CI) were used to estimate the association of MetS and its components with CVD events.Results: The prevalence of MetS among CVD patients was 56.40%, 52.30%, and 23.90% based on the IDF, NCEP ATP III, and WHO criteria, respectively. The highest HR for total CVD (HR: 2.29; 95% CI: 1.54–3.40; P<0.001), UA (HR: 2.13; 95% CI: 1.22 – 3.72; P<0.01), and MI (HR: 3.11; 95% CI: 1.33–7.26; P<0.01) was found when using the WHO definition. The highest HR for SA (HR: 2.56; 95% CI: 1.37 – 4.81; P<0.001) was found when using the NCEP ATP III definition.Conclusion: Having MetS based on the WHO definition was a significant predictor for the incidence of total CVD, MI, and UA, while having MetS based on the ATP III criteria was associated with a higher risk of SA in the MASHAD study population. |
| نویسندگان مقاله |
| Zahra Asadi
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
| Hamideh Ghazizadeh
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. |Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
| Ameneh Timar
Department of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, P.O.Box:397, Sabzevar, Iran.
| Mohammad Amin Khodadadegan
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
| Hamed Ghazavi
Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohammad Nasrabadi
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
| Toktam Sahranavard
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Mohammad Reza Fazl Mashhadi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Mohammad Amin Mohammadi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Arezoo Rastegar-Moghadam
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Ali Ebrahimi Dabagh
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Sara Moazedi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Shadi Kadkhoda-Ahmadi
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Mohammad Reza Shadmand Foumani Moghadam
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Mohanna Zakariaei-Saraji
Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
| Reza Zare-Feyzabadi
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Fatemeh Sadabadi
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Susan Darroudi
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| Afsane Bahrami
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
| Habibollah Esmaily
Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.|Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran.
| Roshanak Ghaffarian Zirak
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
| maryam Tayefi
International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran. |Norwegian Center for E-Health Research, University Hospital of North Norway, Tromsø, Norway.
| Mohsen Moohebati
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Alireza Heidari Bakavoli
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
| Gordon A. Ferns
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK.
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