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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۴، شماره ۳، صفحات ۷۳۰-۷۳۵
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عنوان انگلیسی Determination of Acid Dissociation Constants of Some 2-(3H) –Benzoxazolone Derivatives by UV–Vis Spectrophotometry
چکیده انگلیسی مقاله The acid dissociation constant values of some 2-(3H)-benzoxazolone derivatives were determined in buffered solutions by using the UV-Vis spectrophotometric method. These compounds have benzoxazolone core structures with arylpiperazine substituents and have been investigated for their anti-inflammatory and analgesic activities. The 2-(3H)-benzoxazolone derivatives showed acid dissociation constant values ranging from 8.26 to 9.28. The 5-chloro-2-(3H)-benzoxazolone derivatives exhibit higher acidity than the 2-(3H)-benzoxazolone derivatives. Additionally, a comparison of  5-chloro-2-(3H)-benzoxazolone derivatives showed that derivatives with halogen-containing R2 groups exhibited higher acidity. The findings of this study also suggest that UV–Vis spectrophotometry is one of the most effective techniques for measuring acid dissociation constant values.
کلیدواژه‌های انگلیسی مقاله Benzoxazolone,NSAIDs,pKa,Dissociation Constant,UV-Vis spectrophotometry
نویسندگان مقاله Semra Altunterim Erkan |
Department of Analytical Chemistry, Faculty of Pharmacy, Near East University, Nicosia, NORTH CYPRUS

Hayati Celik |
Department of Analytical Chemistry, Faculty of Pharmacy, Yeditepe University, Istanbul, TURKEY

Banu Kesanlı |
Department of Basic Sciences and Humanities, Faculty of Arts and Sciences, Cyprus International University, Nicosia, NORTH CYPRUS

نشانی اینترنتی https://ijcce.ac.ir/article_722330_fc79095cdb7c2379d64584e3e93164d1.pdf
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