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Iranian Biomedical Journal، جلد ۲۹، شماره ۱، صفحات ۱-۸
عنوان فارسی
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عنوان انگلیسی Role of Gut-Liver Axis in Non-Alcoholic Fatty Liver Disease: A Mini Review
چکیده انگلیسی مقاله Non-alcoholic fatty liver disease has emerged as a significant global health problem, mainly due to the increasing prevalence of obesity and metabolic syndrome. The gut microbiota plays an essential role in the development of NAFLD through the gut-liver axis. Dysbiosis of the GM is associated with the pathogenesis of NAFLD. Dietary choices and other lifestyle factors influence the composition of the GM and contribute to the development of NAFLD. At the phylum level, individuals with NAFLD show an increased level in Actinobacteria and Firmicutes, while Verrucomicrobia, Thermus, Proteobacteria, Lentiphaerae, and Fusobacteria are found to be decreased. Several genera, including Faecalibacterium and Akkermansia, exhibit alterations in NAFLD and are linked to disease progression. Modulating the GM through prebiotics, probiotics, or fecal microbiota transplantation represents a promising therapeutic strategy for NAFLD. This review summarizes the current understanding of GM changes in NAFLD, focusing on findings from both human and animal studies. 
کلیدواژه‌های انگلیسی مقاله Dysbiosis, Gastrointestinal microbiome, Microbiota, Non-alcoholic fatty liver disease
نویسندگان مقاله | Hessam Yaghmaei
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran


| Amirmahdi Taromiha
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran


| Seyed Ali Nojoumi


| Masood Soltanipur
Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran


| Sina Shahshenas
Student Research Committee, Faculty of Medicine, Shahed University, Tehran, Iran


| Mahdi Rezaei
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Seyed Mohsen Mirhosseini
Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Seyyed Mohammad Hosseini
Student Research Committee, Faculty of Medicine, Shahed University, Tehran, Iran


| Seyed Davar Siadat
Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5828-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Molecular Microbiology
نوع مقاله منتشر شده مقاله مروری
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