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Iranian Biomedical Journal، جلد ۲۹، شماره ۱، صفحات ۲۰-۳۵
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عنوان انگلیسی A Novel Approach to Overcome Cisplatin Resistance in Ovarian Cancer: Revealing the Synergistic Potential of Quercetin-Loaded Solid Lipid Nanoparticles
چکیده انگلیسی مقاله Background: Ovarian cancer remains the leading cause of mortality among gynecological cancers, mainly because of resistance to platinum-based chemotherapy, particularly cisplatin. This study investigated the potential of QU-loaded SLNs to address cisplatin resistance in OC cells.
Methods: The efficacy of QU-SLN was assessed in vitro on the cisplatin-resistant SK-OV-3 and cisplatin-sensitive A2780s human OC cell lines. Various assays, including cytotoxicity, cell viability, clonogenicity, flow cytometry, quantitative RT-PCR, and wound healing assays, evaluated the combined effects of QU and QU-SLN with cisplatin on cell viability, apoptosis, gene expression levels related to cisplatin resistance, and cell migration.
Results: Combining QU-SLN with cisplatin resulted in significantly reduced cell viability and colony formation, accompanied by increased apoptotic rates compared to each treatment alone. Moreover, there was a notable reduction in the expression level of genes associated with cisplatin resistance, particularly ABCG2, MT-2A, GST-pi, and XIAP, in the combined treatment. Wound healing assays indicated that the QU-SLN and cisplatin combination severely impaired OC cell motility compared to cisplatin monotherapy.
Conclusion: QU-SLN and cisplatin combination enhances the therapeutic response in cisplatin-resistant OC cells. By reducing cell proliferation, promoting apoptosis, and downregulating drug resistance genes, QU-SLN might present a promising strategy to improve treatment outcomes for OC patients resistant to cisplatin.
کلیدواژه‌های انگلیسی مقاله Nanoparticles, Ovarian neoplasms, Quercetin
نویسندگان مقاله | Masoumeh Shamsi


| Hossien Babaahmadi-Rezaei


| Azam Khedri


| Mahdi Hatami


| Mojtaba Rashidi


نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5543-2&slc_lang=en&sid=1
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