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Iranian Journal of Medical Physics، جلد ۲۲، شماره ۱، صفحات ۴۴-۴۹
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عنوان انگلیسی Enhancing Fricke Xylenol Gel Dosimeter's Response to Radiation with Optimized Preparation Methods
چکیده انگلیسی مقاله Introduction: The fundamental principle of the Fricke gel dosimeter involves the oxidation of ferric ions upon exposure to radiation. However, a significant limitation of this dosimeter is the post-irradiation diffusion of ferric ions, which can result in the degradation of spatial dose information. Material and Methods: Gels were prepared using 300 bloom gelatin, deionized water, sulfuric acid, ferrous ammonium sulfate, and xylenol orange dye (Sigma-Aldrich). The solution was then poured into 10 ml plastic cuvettes.. The gel samples were refrigerated at various temperatures for 1 to 10 days and irradiated within a water bath environment utilizing a telecobalt unit (Phoenix, Theratronics) employing parallel opposed beams. Spectrophotometric analysis at  a wavelength of 585 nm was used to measured optical density changes with dose.. This procedure was repeated across gel formulations prepared under differing pH conditions. Results: The gel's optimum pH value, which was stored for 10 days at 5° C, showed a linear response up to 10 Gy, although the storage time was longer than that of the gels with low (0.3) and high pH (1.3). The auto oxidation rate was determined and found to be less for non-irradiated gel batches stored at 5° C in relation to the gel samples at room temperature and freezing temperature. Conclusion: The dose response of the dosimeter is highly dependent on its pH, composition, alkaline residuals, and pre-irradiation storing conditions.. We observed the optimum pH is 1, at which the dosimeter shows a maximum response. Storing gel samples at 5°C notably reduces the Fe2+ to Fe3+ auto-oxidation rate.
کلیدواژه‌های انگلیسی مقاله Cancer, Radiation Therapy, Fricke Solutions, Spectrophotometry
نویسندگان مقاله | Syed Shajid
Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University.


| ABHIJIT MANDAL
BANARAS HINDU UNIVERSITY


| Kalyan Mondal
Department of Radiotherapy, North Bengal Medical College, Darjeeling, India-734012


| Gogul Priean V
Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University


| Bratindranath Mukherjee
Department of Metallurgical Engineering, Institute of Technology, Banaras Hindu University.


| Praveen Chandra Pandey
Department of Physics, Institute of Technology, Banaras Hindu University


| Himanshu Mishra
Department of Radiotherapy and Radiation Medicine Institute of Medical Sciences Banaras Hindu University VARANASI, Uttar Pradesh, INDIA.


| Ritusha Mishra
RTRM Department, Institute of Medical Sciences, BHU, Varanasi-221005


| Ganeshkumar Patel
RTRM Department, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, INDIA


| Ankur Mourya
Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University.


| Lalit Aggarwal
Institute of Medical Science (BHU)Varanasi, UP, India


| Sunil Choudhary
Department of Radiotherapy and Radiation Medicine Institute of Medical Sciences Banaras Hindu University VARANASI, Uttar Pradesh, INDIA.
نشانی اینترنتی https://ijmp.mums.ac.ir/article_24076.html
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