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Medical Laboratory Journal، جلد ۱۸، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Methotrexate in Rheumatoid Arthritis: Effect on blood indexes, liver and renal parameters in Duhok Governorate, Iraq
چکیده انگلیسی مقاله Background and objectives: Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. The disease may also affect other parts of the body, including the skin, eyes, lungs, heart, nerves, and blood. Aim and objectives: To evaluate the effect of methotrexate on blood, liver, and renal parameters in Rheumatoid arthritis.
Methods: A six-month cross-sectional study was carried out on 60 consecutive patients of aged 19–70 years with diagnosed Rheumatoid arthritis on methotrexate treatment (10 mg) orally per week. A questionnaire form was taken from participants, and laboratory tests were done on renal and liver function and serological tests (complete blood count, erythrocyte sedimentation rate, glutamic pyruvic transaminase, a glutamic-oxaloacetic transaminase, creatinine, C-reactive protein, and rheumatoid factor as follow-up of drug taking).
Results: At the end of sample collection, age 19–70 years, female: male ratio 1.5:1, while the only significant differences in platelet level were between day one and fourteen of treatment with a P value < 0.05, Glutamic Pyruvic Transaminase (GPT) level was between day one and thirty with a P value < 0.05, and rheumatoid factor level was between day one, fourteen, and day one, thirty with P values of (0.01) and (0.04) respectively which were significant.
Conclusion: The recommended medication for all kinds of rheumatoid arthritis patients is methotrexate, which has had a notable impact on blood, liver, and kidney parameters. These characteristics could be used to track how well this medication works, how safe it is, and to follow up with patients.
کلیدواژه‌های انگلیسی مقاله C - reactive protein, Glutamic-Oxaloacetic Transaminase, Glutamic-Pyruvic Transaminase, Hemoglobins, Methotrexate, Rheumatoid
نویسندگان مقاله | Beri Tawfeq
Medical Laboratory Sciences/college of health sciences/Duhok University/Iraq.Duhok


| Bizav Rasheed
Department of Nursing, College of Health and Medical Techniques-Shekhan, Duhok Polytechnic University, Duhok, Iraq
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-1777-2&slc_lang=en&sid=1
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