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Basic and Clinical Neuroscience، جلد ۱۶، شماره ۲، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The Assessments of Electrocardiographic Parameters in the Patients with Drug-Resistant Temporal Lobe Epilepsy; A Case-Control Study
چکیده انگلیسی مقاله
Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls.
Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability.
Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05).
Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.
کلیدواژه‌های انگلیسی مقاله Sudden Unexpected Death in Epilepsy, Temporal lobe epilepsy, Cardiac arrhythmia, Electrocardiography
نویسندگان مقاله | Jafar Mehvari
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.


| Zeinab Jaafari
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.


| Mohamad Zare
Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.


| Nasim Tabrizi
Epilepsy Subspecialist, Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.


| Alireza Khosravi Farsani
Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-4724-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Clinical Neuroscience
نوع مقاله منتشر شده Original
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