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Basic and Clinical Neuroscience، جلد ۱۶، شماره ۲، صفحات ۰-۰
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عنوان انگلیسی The Mitochondrial Toxicity Induced by 3-Nitropropionic Acid Enhanced Susceptibility to Defective Social Behaviors in Male Wistar Rats: Possible Role of Glucocorticoid Receptor and FKBP5
چکیده انگلیسی مقاله
The impaired mitochondrial function in neurons is a core abnormality in many medical conditions. Behavioral changes are the key aspects that emerge under these conditions. In the current study, we investigated whether social interactions are influenced by 3-nitropropionic acid (3-NP)-induced mitochondrial failure. We also assessed changes in glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities in the striatum, hippocampus, and prefrontal cortex of the subjects. Adult male Wistar rats were treated with 3-NP. The social and non-social behaviors of 3-NP-treated rats were investigated. Different dissected brain regions were considered in terms of glucocorticoid receptor and FKBP5 protein levels, cytochrome contents, and monoamine oxidase A and B activities. We found a significantly decreased duration of social behaviors along with impaired non-social behavioral tests in the striatum, hippocampus, and prefrontal cortex. We detected a decreasing trend in the levels of glucocorticoid receptor and FKBP5 protein. Moreover, cytochrome contents and monoamine oxidase A and B activities decreased in the dissected brain regions. Impaired social/non-social behaviors along with decreased levels of investigated molecular variables in the aforementioned regions after 3-NP treatment might point to processes connecting mitochondrial failure to behavioral impairment, particularly social type.
کلیدواژه‌های انگلیسی مقاله 3-NP, Glucocorticoid receptor, FKBP5, Cytochrome, Monoamine oxidase, Social behavior
نویسندگان مقاله | Fatemeh Nasehi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Fariba Khodagholi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Neda Kaveh
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Ali Maleki
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Arman Zeinaddini-Meymand
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Maryam Alsadat Mousavi
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Dariush Minai-Tehrani
Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran.


| Forough Foolad
Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی http://bcn.iums.ac.ir/browse.php?a_code=A-10-6604-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Behavioral Neuroscience
نوع مقاله منتشر شده Original
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