این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۳، صفحات ۱۱۶۷-۱۱۷۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective effect of menthol against diethylnitrosamine-induced hepatocellular carcinoma in mice by downregulating CTNNB1 and HIF-1α
چکیده انگلیسی مقاله Objective: This study examined the impact of menthol, a natural monoterpene, on diethylnitrosamine (DEN)-induced molecular and histopathological changes in the livers of male mice.Materials and Methods: Forty male mice were divided into four groups: Control, Menthol (M), DEN, and DEN-M. The DEN and DEN-M groups received an intraperitoneal injection of DEN (25 mg/kg) at the age of 14 days. The M and DEN-M groups were also given menthol (50 mg/kg, three times a week for six months) via gavage. The expression of genes related to liver carcinoma was analyzed using real-time PCR. Subsequently, the liver tissue was microscopically examined following staining with hematoxylin-eosin.Results: After one month, menthol reduced the infiltration of inflammatory cells in the liver tissue of mice injected with DEN. It also prevented the increase in the expression of alpha-fetoprotein (AFP) (p<0.001), programmed cell death 6 (p<0.05), hypoxia-inducible factor-1 alpha (HIF-1α) (p<0.001), and vascular endothelial growth factor (VEGF) (p<0.001) in DEN-M animals compared with DEN group. After six months of session, the expression of AFP (p<0.05), HIF-1α (p<0.05), secreted frizzled-related protein 1 (p<0.001), and catenin beta 1 (p<0.01) was lower in group DEN-M compared with group DEN. Menthol also partially prevented DEN-induced various histopathological changes in the liver after six months of treatment.Conclusion: We concluded that menthol inhibits Wnt signaling and suppresses the expression of HIF-1α and VEGF in the liver of DEN-injected mice. It is probably a suitable option for the prevention and treatment of hepatocellular carcinoma.
کلیدواژه‌های انگلیسی مقاله Monoterpenes, Wnt signaling pathway, Angiogenesis, Alpha-fetoprotein, Liver
نویسندگان مقاله | Zahra Mollaei
Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran


| Masoumeh Asle-Rousta
Department of Physiology, Islamic Azad University, Zanjan Branch, Zanjan, Iran


| Golnaz Asaadi Tehrani
Department of Genetics, Zanjan Branch, Islamic Azad University, Zanjan, Iran. Aerospace and Mechanical Engineering Department, Notre Dame University, Indiana, USA
نشانی اینترنتی https://ajp.mums.ac.ir/article_25230.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات