این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۳، صفحات ۱۱۷۷-۱۱۹۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The hydroalcoholic extract of Nasturtium officinale protectively inhibits apoptotic and inflammatory pathways in hepato- and nephrotoxicity: An in vivo study
چکیده انگلیسی مقاله Objective: Nasturtium officinale (N. officinale (NO)) has been widely used in traditional medicine. This study investigates the protective effects of NO against hepatic and renal damage induced by CCl4 and gentamicin, respectively, in rats.Materials and Methods: Male Wistar rats were divided into two arms: A (CCl4-induced hepatotoxicity) and B (gentamicin-induced nephrotoxicity). Seventeen groups were formed by dividing arms A and B, with nine groups in arm A and eight groups in arm B (n=5). Rats were daily treated with various doses (50, 100, and 200 mg/kg BW) of N. officinale extract (NOE) (Total extract; Oral gavage) for 14 and 28 days in arm A and B, respectively. Biochemical and histopathological evaluations and gene expression analyses were conducted on blood, liver, and kidney tissues.Results: NOE treatment significantly modulated B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and B-cell lymphoma protein 2 (Bcl-2) expression in kidney tissue, reducing Bax (p<0.01) and increasing Bcl-2 (p<0.05). In liver tissue, NOE inhibited tumor necrosis factor alpha (TNF-α) (p<0.01) and Interleukin-1 beta (IL-1β) (p<0.001), while reducing AST and ALT activity (p<0.001). Additionally, blood urea nitrogen (BUN) levels significantly decreased (p<0.05) in nephrotoxic rats.Conclusion: Our findings highlight the capability of NOE as a promising therapeutic against liver and kidney damage induced by CCl4 and gentamicin, respectively, in animal models.
کلیدواژه‌های انگلیسی مقاله Nephrotoxicity, Hepatotoxicity, Nasturtium officinale, Inflammation, Apoptosis
نویسندگان مقاله | Sevil Soudkhah
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Sahar Keyghobadi
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Amir Shadboorestan
Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran


| Mahdi Gholami
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Behnam Omidi Sarajar
Department of toxicology and pharmacology, faculty of pharmacy,Tehran university of medical sciences,Tehran,Iran


| Armin Salek Maghsoudi
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Mahmoud Omidi
Department of Toxicology and Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Hormozgan University of Medical Sciences


| Saeed Mohammadi Motamed
department of Pharmacognosy, Pharmaceutical sciences Branch, islamic Azad University, Tehran, Iran


| Saeid Akbarzadeh Kolahi
Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Nima Rastegar-Pouyani
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences (TUMS), Tehran, Iran


| Shokoufeh Hassani
Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
نشانی اینترنتی https://ajp.mums.ac.ir/article_25213.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Research Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات