| چکیده انگلیسی مقاله |
Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 is associated with schizophrenia and its negative symptoms in an Iranian population. Method: Rs2439272 was genotyped in 469 participants including 276 unrelated patients with schizophrenia and 193 healthy controls. The association of genetic risk with PANSS, and negative symptoms was examined in the total, male and female samples. COCAPHASE and CLUMP22 programs were used to compare the allele and genotype frequencies, and general linear regression was used to analyze the quantitative dependent variables by the selected variant. Results: In this study, it was revealed that the G allele of rs2439272 might be an allele with the increased risk of developing schizophrenia, especially in the male participants. In addition, significant differences were found between the G allele and GG genotype frequencies and PANSS, and negative symptoms in the total and male participants. Conclusion: Our results supported the association between rs2439272 in NRG1 gene and risk of schizophrenia and its negative symptoms in an Iranian population. |
| نویسندگان مقاله |
صادق یوسفی | sadegh yoosefee
neuroscience and neurology research center, qom university of medical sciences, qom, iran. and department of neuroscience, school of advanced technologies in medicine, iran university of medical sciences iums , tehran, iran. and health and religion research center, qom university of medical sciences, qom, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی قم (Qom university of medical sciences)
اسماعیل شاهسوند آنانلو | esmaeil shahsavand ananloo
department of adult psychiatry, roozbeh hospital, school of medicine, tehran university of medical sciences tums , tehran, iran. and department of genomic psychiatry and behavioral genomics dgpbg , roozbeh psychiatry hospital, school of medicine, tehran university of medical sciences tums , tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد تقی جغتایی | mohammad taghi joghataei
department of neuroscience, school of advanced technologies in medicine, iran university of medical sciences iums , tehran, iran.
مرتضی کریمی پور | morteza karimipour
molecular medicine group, pasteur institute of iran.
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
محمودرضا حاجی قاسم | mahmoudreza hadjighassem
department of neuroscience and addiction studies, school of advanced technologies in medicine, tehran university of medical sciences tums , tehran, iran.
حوریه محقق | hoorie mohaghghegh
department of neuroscience and addiction studies, school of advanced technologies in medicine, tehran university of medical sciences tums , tehran, iran.
مهدی تهرانی دوست | mehdi tehrani doost
department of child and adolescent psychiatry, roozbeh hospital, school of medicine, tehran university of medical sciences tums , tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
امیر عباس رحیمی | amir abbas rahimi
molecular medicine group, pasteur institute of iran.
سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)
حمید مصطفوی عبدالملکی | hamid mostafavi abdolmaleky
department of genetics amp;amp; genomics, boston university school of medicine, boston, ma, united states.
مریم حاتمی | maryam hatami
department of adult psychiatry, roozbeh hospital, school of medicine, tehran university of medical sciences tums , tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
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