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Iranian Journal of Public Health، جلد ۴۴، شماره ۲، صفحات ۲۶۳-۸
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عنوان انگلیسی Predictive Power of ETRE Polymorphism and Katg463 Mutation to INH-Resistance of M.tuberculosis.
چکیده انگلیسی مقاله The MIRU-VNTR polymorphism and katG463 mutation are used to genotype the mycobacterium tuberculosis, but the correlation between them and INH-resistance were unknown. This study was aimed to explore whether ETRE polymorphism and katG463 mutation could predict the INH-resistance, and the relationship between ETRE polymorphism and katG463 mutation.The ETRE, katG463 mutation and drug resistance information of 109 M. tuberculosis strains were collected from online public database. We constructed the predictive diagnostic tool of ETRE polymorphism and katG463 mutation. Chi-square test was used to analyze the relationship between ETRE polymorphism, katG463 mutation and INH-resistance. ROC curve analysis and Z-test were used to evaluate the predictive ability of ETRE and katG463. The relationship between ETRE polymorphism and katG463 mutation was analyzed with Spearman correlation analysis.The mutation rate of katG463 was 27.50%, and the h value of ETRE polymorphism was 0.67. KatG463 mutation was associated with INH resistance (OR=3.72). The INH drug resistance rate in VNTR≧5 group was 3.43 times higher than that in VNTR≦3 group (χ(2) =24.77, P< 0.01), and there was no significant difference of INH resistance between the VNTR=4 group and VNTR≦3 group. The areas under the ROC curve of two loci prediction diagnostic tools were 0.64 and 0.70 respectively. The katG463 mutation was significantly related to the ETRE polymorphism (r=0.79, P< 0.01).Both katG463 mutation and the ETRE polymorphism can predict the INH-resistance of tuberculosis. The katG463 mutation was associated with ETRE VNTR polymorphism.
کلیدواژه‌های انگلیسی مقاله Drug resistance,ETRE,M.tuberculosis,VNTR,katG463
نویسندگان مقاله yu feng wen | yu feng wen
school of public health, wan nan medical college, wuhu, china.


chao jiang | chao jiang
school of public health, wan nan medical college, wuhu, china.


xian feng چنگ | xian feng cheng
school of public health, wan nan medical college, wuhu, china.


zhi ping زانگ | zhi ping zhang
centre for disease prevention and control of anqing city, anqing, china.


بای feng chen | bai feng chen
school of public health, wan nan medical college, wuhu, china.


yu zhu | yu zhu
school of public health, wan nan medical college, wuhu, china.
نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/3680
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-350170.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Articles
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