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Iranian Journal of Toxicology، جلد ۱۹، شماره ۳، صفحات ۰-۰
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عنوان انگلیسی Ameliorative effect of Periwinkle diet on lipid profile and some biochemical parameters in Phenylhydrazine-induced derangements
چکیده انگلیسی مقاله Background: Anaemia is a haematological anomaly characterized by the deficiency of Red blood cell (RBC) count, Haemoglobin content and Packed cell volume (PVC). It is a serious global health concern that particularly affects young children and pregnant women, WHO estimates that 42% of children less than 5 years of age and 40% of pregnant women worldwide are anaemic. Periwinkles are water-bodies resources of substantial economic value in the world of fisheries. They form vital source of protein and are deposited in different water bodies. seafoods are abundant sources of selenium, Vit A, Vit D, Vit E, Vit B12, Vit B6, thiamine, proteins and essential fatty acid. They have also been shown to enhance erythropoiesis.
The aim of this study is to investigate the biochemical boosting capacity of TFD (having high antioxidants, vitamins and mineral content) and other associated parameters on Wistar rats following Phenylhydrazine (PHZ)-induced hemolytic anemia and possible mechanism of action.
Methods: Twenty-four [24] male Wistar rats weighing between 180-250g were used for this study. The rats were randomly assigned into 4 groups (n = 6). Group 1: (Control) received normal feed and drinking water. Group 2: received 600 mg/kg body weight of TFD orally. Group 3: received PHZ at a dose of 40 mg/kg body weight (IP). Group 4: received same as group 2 (600 mg/kg body weight of TFD orally) plus group 3 (40mg/kg body weight of PHZ, intraperitoneally). The research lasted for forty-two (42) days, thereafter the rats were sacrificed and blood samples collected for relevant analysis.
Result: The result shows an increase (P<0.05) in Low density lipoprotein-cholesterol, Total cholesterol, Triglyceride, Cardiac risk ratio, Atherogenic coefficient, Atherogenic index in plasma, Malondialdehyde, Alanine transaminase, Alkaline phosphatase, Aspartate transaminase, Na+, Cl-, Total bilirubin, Unconjugated bilirubin, urea, uric acid and creatinine in PHZ group compare to control and TFD group but were reversed i.e. decreased (P<0.05) in PHZ+TFD group compared to PHZ group. High density lipoprotein-cholesterol, Catalase, Superoxide dismutase, Glutathione peroxidase, Total protein, Albumin, Globulin, K+, HCO3-, Fe2+, Ca2+ and CB were all decreased (P<0.05) in PHZ group compared to control and TFD but they were all increased (P<0.05) in the PHZ+TFD group compared to PHZ.
Conclusion: PHZ-induction in Wistar rats is associated with atherogenic and hepatoxic impairment. TFD diet ingestion is capable of ameliorating this condition via modulation of pro/ antioxidant activities.
کلیدواژه‌های انگلیسی مقاله Seafood, Periwinkle, Tympanotonos fuscatus, Phenylhydrazin and Anemia
نویسندگان مقاله | Archibong Archibong
Department of Human Physiology, University of Calabar, Calabar- Nigeria


| Sonnie Oyama
Department of Family Medicine, University of Alberta, Canada


| Sam Uquetan
Department of Human Physiology, University of Calabar, Calabar- Nigeria


| Irene Etim
Department of Human Physiology, University of Calabar, Calabar- Nigeria


| Effioanwan Orji
College of Nursing and Midwifery Sciences, Itighidi, Cross River State-Nigeria


| Charles Mfem
Department of Human Physiology, University of Calabar, Calabar- Nigeria


| Daniel Owu
Department of Human Physiology, University of Calabar, Calabar- Nigeria


| Ofem Ofem
Department of Human Physiology, University of Calabar, Calabar- Nigeria
نشانی اینترنتی http://ijt.arakmu.ac.ir/browse.php?a_code=A-10-1351-1&slc_lang=en&sid=1
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