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Archives of Breast Cancer، جلد ۱۲، شماره ۲، صفحات ۲۳۶-۲۳۹

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عنوان انگلیسی Secondary ALK-Positive Anaplastic Large Cell Lymphoma Masquerading as Inflammatory Breast Cancer: Race and management of IGM
چکیده انگلیسی مقاله Background: Secondary breast lymphoma accounts for 0.12% of breast malignancies. Anaplastic large cell lymphoma (ALCL) metastases to the breast are rare considering lymphoid tissue is a minor component of the breast. We describe a case of secondary ALK-positive ALCL identified during workup of inflammatory breast cancer in the setting of diffuse erythema, induration, and pitting lymphedema of the right breast with weeping serous fluid in a septic patient. Case Presentation: A 28-year-old female presented with septic shock and two weeks of right breast pain, erythema, swelling, and fever.  Imaging demonstrated a mass in the right axillary/sub-pectoral region and bilateral axillary, mediastinal, supraclavicular, and retroperitoneal lymphadenopathy. Physical exam demonstrated tenderness, diffuse erythema, induration, pitting lymphedema of the right breast with palpable lymphadenopathy concerning for inflammatory breast cancer. Punch biopsy was performed. Immunohistochemical analysis revealed CD30 and CD45 positivity. Fluorescent in-situ hybridization (FISH) reflex revealed ALK (2p23). Subsequent nodal biopsies revealed hallmark cells. The cumulative findings were indicative of ALK-positive ALCL.  Conclusion: This presentation underscores the importance of including lymphoma within the differential during workup of suspected inflammatory breast cancer.
کلیدواژه‌های انگلیسی مقاله breast cancer, inflammatory breast cancer, anaplastic large cell lymphoma, lymphoma

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نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1038
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کد مقاله (doi) 10.32768/abc.2025122236-239
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Case Report
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