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Iranian Journal of Veterinary Medicine، جلد ۱۸، شماره Special Issue، صفحات ۶۶۱-۶۷۲
عنوان فارسی سنسور الکتروشیمیایی مبتنی بر اتر کراون پلیمری Thia برای تعیین کاربامازپین و افدرین
چکیده فارسی مقاله
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عنوان انگلیسی Electrochemical Sensor Based on Crafted Thia Polymeric Crown Ether for Determination of Carbamazepine and Ephedrine
چکیده انگلیسی مقاله Background: Direct analysis methods are considered some of the best and easiest tools to quickly determine the amount of active drug in some pharmaceutical preparations. Objectives: In this study, an ion electrode is prepared to determine the concentration of a sample of ephedrine (Eph) and carbamazepine (CBZ) in the medicines produced by some companies directly.
Methods: CBZ and Eph drugs ion-selective electrode (ISE) based on Thia polymeric crown ether (SPCE-CZB and SPCE-Eph) as membrane carrier in polyvinyl chloride (PVC) matrix was successfully fabricated for the determination of CBZ and Eph drugs.  
Results: The electrode exhibited a liner Nernstian slope response over the range of 1×10-1 to 1×10-6 M, and 1×10-5 to 1×10-1 with a slope of 28 and 33±2 mV per decade charge, respectively, by using dimethyl phthalate plasticizer and a detection limit of 1×10-9 M. The response time of the sensor was 10 s. The ISE showed a greater preference for CBZ and Eph over other drugs with good precision.
Conclusion: The selectivity coefficients of some drugs ranged from 1×10-5 to 1×10-1. Meanwhile, SPCE-CZB (ISE) was successfully used as an indicator electrode for the potentiometric determination of the CBZ drug pharmaceutical formulas. 
کلیدواژه‌های انگلیسی مقاله Carbamazepine (CBZ),Ephedrine (Eph),Ion-selective electrode (ISE),Thia polymeric crown ether,Potentiometric sensor
نویسندگان مقاله Hussain Najam |
Department of Medical Laboratory Technique, Altoosi University College, Najaf, Iraq.

Abdullah Shakir |
Najaf Technical Institute, Al-Furat Al-Awsat Technical University, Najaf, Iraq.

Sara Muhsan |
Department of Chemistry, College of Medical Technology, The Islamic University, Najaf, Iraq.

Fadhil Faez Sead |
Department of Chemistry, College of Medical Technology, The Islamic University, Najaf, Iraq.

Hussein Jasim Mohammed |
Department of Chemistry, Faculty of Science, University of Kufa, Iraq.

نشانی اینترنتی https://ijvm.ut.ac.ir/article_100117_b17eb4b4828ace0d3040c81da637c7d1.pdf
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