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Iranian Journal of Veterinary Medicine، جلد ۱۸، شماره Special Issue، صفحات ۶۹۷-۷۰۲
عنوان فارسی مطالعات ضد سرطان Cydonia Oblonga کشت شده در عراق از خانواده Rosaceae
چکیده فارسی مقاله
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عنوان انگلیسی Anticancer Studies of Iraqi-cultivated Cydonia Oblonga From the Family of Rosaceae
چکیده انگلیسی مقاله Background: Cydonia oblonga Miller is a plant that provides numerous phytochemical benefits that could be used in medicine, such as flavones, flavonols, and their glycosides, in addition to different vitamins and minerals.
Objectives: This study evaluates the in vitro cytotoxic activity of C. oblonga ethyl acetate of two plant parts (fruit and seeds) against human colon cancer cells (Caco-2) using the MTT assay method. 
Methods: In this study, two parts of the C. oblonga plant were used (seeds and fruit) and extracted by using different organic solvents, such as 98% hexane, 80% ethanol, and ethyl acetate. The ethyl acetate extract of both parts was used to evaluate the cytotoxic activity of C. oblonga on human colon cancer cells (Caco-2) by using the MTT assay method.
Results: The ethyl acetate extract of seeds had no considerable cytotoxic effect (P>0.1), while the fruit extract showed a significantly high antiproliferative effect compared to the oxaliplatin anticancer drug (P<0.1).
Conclusion: The fruit ethyl acetate extract of the quince plant gives significant anticancer activity against colon cancer cells as compared to seed extract which showed no effect. 
کلیدواژه‌های انگلیسی مقاله anticancer,Caco-2,Cydonia,Ethyl acetate,MTT 
نویسندگان مقاله Noor Salman Obaid |
Department of Pharmacognosy, College of Pharmacy, Karbala University, Karbala, Iraq.

Raghad Abdulmahdi Mohsin |
Department of Pharmacology and Toxicology, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.

Ahmed Mohammed Jawad Jehan Yin |
Department of Pharmaceutical Chemistry, College of Pharmacy, Karbala University, Karbala, Iraq.

نشانی اینترنتی https://ijvm.ut.ac.ir/article_100121_720b45cfc281e5caa040ef32e7995f4c.pdf
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