این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Veterinary Medicine، جلد ۱۸، شماره Special Issue، صفحات ۷۲۵-۷۳۴
عنوان فارسی چالش‌های تشخیص لباس ناشی از لاموتریژین: یک مورد منحصر به فرد از کوله سیستیت حسابی در صرع
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Challenges in Diagnosing Lamotrigine-induced DRESS: A Unique Case of Acalculous Cholecystitis in Epilepsy
چکیده انگلیسی مقاله Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an infrequent yet severe idiosyncratic reaction to drugs, characterized by a diverse range of systemic manifestations and a mortality rate of 10% to 20%. Commonly associated with anticonvulsant drugs and sulfonamides, DRESS syndrome poses diagnostic challenges due to its variable presentation. This study presents a unique case of lamotrigine-induced DRESS associated with acalculous cholecystitis, an unprecedented manifestation. The patient, initially treated with levetiracetam and lamotrigine for generalized epilepsy, experienced a delayed onset of symptoms, with a European registry of severe cutaneous adverse reactions (RegiSCAR  score of 7, confirming the diagnosis. Reactivation of Epstein-Barr virus was detected, suggesting a potential link between herpesvirus reactivation and DRESS pathogenesis. The case underscores the importance of careful monitoring and consideration of atypical organ involvement in DRESS diagnosis. Lamotrigine withdrawal resulted in rapid clinical resolution, allowing for a cautious transition to an alternative anti-epileptic medication which is valproate. This case contributes to the evolving understanding of DRESS syndrome, emphasizing the need for a comprehensive diagnostic approach in complex medication regimens. 
کلیدواژه‌های انگلیسی مقاله Acalculous cholecystitis,Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome,Herpesvirus reactivation,Lamotrigine
نویسندگان مقاله Safa Akeel Al-Hasan |
Department of Surgery, Faculty of Medicine, Kufa University, Kufa, Iraq.

Ali Abdulkareem Al-Fahham |
Department of Ophthalmology, Najaf Teaching Hospital, Najaf, Iraq.

Samih Akeel Al-hasan |
Department of Surgery, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Najaf, Iraq.

Baraa Akeel Al-Hasan |
Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq.

Fatma Akeel Al-Hasan |
Department of pharmacy, Najaf Teaching Hospital, Najaf, Iraq.

Ahmed Maki Radeef |
Department of Anesthesia Techniques, College of Health and Medical Techniques, Al-Mustaqbal University, Babylon, Iraq.

Haider Abbas Hadi Al-Mhanaa |
College of Nursing, Al-Mustaqbal University, Babylon, Iraq.

Ali Salah Wadday |
Department of Animal Husbandry, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.

Ghadeer Sabah Bustani |
Department of Medical Laboratory Technology, College of Medical Technology, The Islamic University, Najaf, Iraq.

نشانی اینترنتی https://ijvm.ut.ac.ir/article_100113_e5817f6ef8c609845e4754511759a7ec.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات