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Iranian Journal of Medical Sciences، جلد ۵۰، شماره ۵، صفحات ۲۷۸-۳۰۳
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عنوان انگلیسی Uncovering Novel Anti-Lung Cancer Compounds: Insights from Marine Sponge-Derived Agents: A Bibliometric Review
چکیده انگلیسی مقاله Background: Lung cancer remains a leading cause of cancer-related mortality, necessitating improved treatment strategies. This study collectively highlights the valuable potential of marine sponges as a source for discovering new anti-tumor agents.
Methods: We conducted a bibliometric analysis to identify anticancer compounds from marine sponges using PubMed (2018–2023). The search included keywords such as “marine sponge,” “cancer,” “neoplasm,” “proliferation,” “cytotoxicity,” “tumor,” “sesquiterpene,” “alkaloid,” and “quinones.” Inclusion criteria focused on studies related to lung cancer and marine sponge-derived compounds, excluding non-cytotoxic activities and unrelated species. Data were extracted in comma-separated values (CSV) format and analyzed via VOSviewer. Molecular docking identified compounds with strong binding to apoptotic receptors in lung cancer cells. PROTOX and Way2Drug tools predicted the pharmacological properties of selected compounds as potential drugs.
Results: The bibliometric analysis identified alkaloids, sesquiterpenes, and quinones as key keywords. Dactyloquinone B-D, dysidavarone D, smenohamien F, and sollasin E demonstrated strong binding to apoptotic receptors in lung cancer cells, suggesting potential as anti-lung cancer drugs. Pharmacological analyses revealed promising effects and potential side effects, highlighting their suitability for further drug development. These findings provide a foundation for novel targeted therapies for lung cancer.
Conclusion: This study highlights the potential of alkaloids and sesquiterpenes derived from marine sponges as promising anti-lung cancer agents, emphasizing the need for further in vitro, in vivo, and clinical investigations to validate their therapeutic efficacy.
کلیدواژه‌های انگلیسی مقاله Lung Neoplasms,Porifera,Antineoplastic agents,Bibliometrics,apoptosis
نویسندگان مقاله Afshin Zare |
PerciaVista R&D Co., Shiraz, Iran

Alireza Afshar |
PerciaVista R&D Co., Shiraz, Iran

Nadiar M Mussin |
Department of General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Asset A Kaliyev |
Department of General Surgery, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Raisa A. Aringazina |
Department of Internal Medicine No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Nader Tanideh |
PerciaVista R&D Co., Shiraz, Iran

Mahdi Mahdipour |
Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Farhad Rahmanifar |
Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

Zhanna Zhussupova |
Department of Neurology, Psychiatry and Narcology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Beibyt Tlektesuly Baizakov |
Department of Radiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Amin Tamadon |
PerciaVista R&D Co., Shiraz, Iran

نشانی اینترنتی https://ijms.sums.ac.ir/article_50871_323f20d90fc6c4d933ac820dd8290d6d.pdf
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