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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۱، صفحات ۱-۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Development of a nanoprecipitation method for the entrapment of a very water soluble drug into Eudragit RL nanoparticles
چکیده انگلیسی مقاله Rivastigmine hydrogen tartrate (RHT), one of the potential cholinesterase inhibitors, has received great attention as a new drug candidate for the treatment of Alzheimer's disease. However, the bioavailability of RHT from the conventional pharmaceutical forms is low because of the presence of the blood brain barrier. The main aim of the present study was to prepare positively charged Eudragit RL 100 nanoparticles as a model scaffold for providing a sustained release profile for RHT. The formulations were evaluated in terms of particle size, zeta potential, surface morphology, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC). Drug entrapment efficiency and in vitro release properties of lyophilized nanoparticles were also examined. The resulting formulations were found to be in the size range of 118 nm to 154 nm and zeta potential was positive (+22.5 to 30 mV). Nanoparticles showed the entrapment efficiency from 38.40 ± 8.94 to 62.00 ± 2.78%. An increase in the mean particle size and the entrapment efficiency was observed with an increase in the amount of polymer. The FTIR, XRD, and DSC results ruled out any chemical interaction between the drug and Eudragit RL100 polymer. RHT nanoparticles containing low ratio of polymer to drug (4:1) presented a faster drug release and on the contrary, nanoparticles containing high ratio of polymer to drug (10:1) were able to give a more sustained release of the drug. The study revealed that RHT nanoparticles were capable of releasing the drug in a prolonged period of time and increasing the drug bioavailability.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سارا سلاطین | sara salatin
1research center for pharmaceutical nanotechnology, tabriz university of medical science, tabriz, i.r. iran. 2student research committee, tabriz university of medical science, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

ژاله barar | jaleh barar
1research center for pharmaceutical nanotechnology, tabriz university of medical science, tabriz, i.r. iran. 3department of pharmaceutics, faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محمد برزگر جلالی | mohammad barzegar jalali
3department of pharmaceutics, faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

خسرو adibkia | khosro adibkia
3department of pharmaceutics, faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran. 4drug applied research center and faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

فرهاد کیافر | farhad kiafar
3department of pharmaceutics, faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran. 5zahravi pharmaceutical company, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

میترا جلوه گری | mitra jelvehgari
3department of pharmaceutics, faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran. 4drug applied research center and faculty of pharmacy, tabriz university of medical sciences, tabriz, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1736
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350608.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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