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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۱، صفحات ۳۱-۳۷
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عنوان انگلیسی In vitro antioxidant and cytotoxic potential of different parts of Tephrosia purpurea
چکیده انگلیسی مقاله The antioxidant and cytotoxic properties of four major parts of methanolic extracts of Tephrosia purpurea including leaves, root, stem and seed were investigated and compared. In vitro antioxidant activity of T. purpurea extracts was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), reducing power assay and antihemolytic assay. In vitro cytotoxic effect of T. purpurea extracts on SW620 colorectal cancer cell line was studied using 3-(4, 5-dimethylthiazolyl -2,5-diphenyl-tetrazolium bromide (MTT) assay. Folin-ciocalteu and aluminium chloride methods were used to determine the total phenolic and flavonoid contents respectively. Among the four extracts studied, leaves extract showed the highest antioxidant activity, DPPH: 186.3 ± 14.0 µg/mL, FRAP: 754.2 ± 50.9 μmol Fe(II)/mg and reducing power activity: 65.7 ± 4.2 µg/mg of quercetin equivalent (QE/mg) and there was no significant difference observed in antihemolytic activity. Leaves extract showed effective cytotoxicity on colorectal cancer cells (IC 50 : 95.73 ± 9.6 μg/mL) and also had the higher total phenolic (90.5 ± 6.7 μg/mg of gallic acid equivalent (GAE/mg) and flavonoid content (21.8 ± 5.4 µg QE/mg). These results suggest higher antioxidant and cytotoxic activities of leaves extract in comparison with other extracts and these activities could be due to the presence of rich phenolic and flavonoid content.
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نویسندگان مقاله ramamoorthy padmapriya | ramamoorthy padmapriya
1department of pharmacology, jipmer, puducherry 605006, india.


sankar ashwini | sankar ashwini
2department of biochemistry, jipmer, puducherry 605006, india.


ramasamy raveendran | ramasamy raveendran
1department of pharmacology, jipmer, puducherry 605006, india.
نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1740
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350611.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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