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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۱، صفحات ۳۸-۴۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Radioprotective effects of lentil sprouts against X-ray radiation
چکیده انگلیسی مقاله The present study investigated the radioprotective efficacy of lentil ( Lens culinaris ) sprouts against X-ray radiation-induced cellular damage. Lentil seeds were dark germinated at low temperature and the sprout extract was prepared in PBS. Free radical scavenging of extract was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and then the radioprotective potency of extract (0 to 1000 µg/mL) on the lymphocyte cells was determined by lactate dehydrogenases assay. Moreover, micronuclei assay was assessed using the cytokinesis-block technique. The irradiations were performed using 6 MV X-ray beam. The value of IC 50 for DPPH assay was 250 µg/mL. The median lethal dose for radiation was determinate at 5.37 Gy. Pretreatment with lentil sprout extract at 1000 µg/mL reduced cytotoxicity at 6 Gy total concentration from 70% to 50%. The results of micronuclei assay indicated that cells were resistant to radiation at concentrations of 500-1000 µg/mL of exogenous lentil sprout extract. The value of median effective concentration for micronuclei assay was 500 µg/mL. The results indicated that lentil sprout extract showed actually somewhat radioprotective effect on lymphocyte cell. In addition, the obtained results suggest that extract of total lentil sprout have more antioxidant activity than radicle part.
کلیدواژه‌های انگلیسی مقاله Radioprotective agents,Germination,X-Radiation,Legumes
نویسندگان مقاله عباس حق پرست | abbas haghparast
1department of medical physics, faculty of medicine, kermanshah university of medical sciences, kermanshah, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

کامران منصوری | kamran mansouri
2medical biology research center, kermanshah university of medical sciences, kermanshah, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

سمانه مرادی | samane moradi
3research center of oils and fats, food and drug administration, kermanshah university of medical sciences, kermanshah, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

فاطمه داداشی | fatemeh dadashi
3research center of oils and fats, food and drug administration, kermanshah university of medical sciences, kermanshah, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

سعید الیاسی | saeed eliasi
4radiation oncology center, imam reza hospital, kermanshah, i.r. iran.


مهدی سبحانی | mahdi sobhani
4radiation oncology center, imam reza hospital, kermanshah, i.r. iran.


کامبیز ورمیرا | kambiz varmira
3research center of oils and fats, food and drug administration, kermanshah university of medical sciences, kermanshah, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1741
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350612.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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