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Research in Pharmaceutical Sciences، جلد ۱۲، شماره ۱، صفحات ۸۲-۸۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes
چکیده انگلیسی مقاله Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells. The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced by ionizing radiation in cultured human blood lymphocytes. Peripheral blood samples were collected from human volunteers and were incubated at different concentrations at 1, 5, 10 and 50 μM of CLX for two hours. At each dose point, the whole blood was exposed in vitro to 150 cGy of X-ray, and then the lymphocytes were cultured with mitogenic stimulation to determine the micronucleus frequency in cytokinesis blocked binucleated lymphocytes. Incubation of the whole blood with CLX exhibited a significant decrease in the incidence of micronuclei in lymphocytes induced by ionizing radiation, as compared with similarly irradiated lymphocytes without CLX treatment. The maximum reduction on the frequency of micronuclei was observed at 50 μM of CLX (65% decrease). This data may have an important possible application for the protection of human lymphocytes from the genetic damage induced by ionizing irradiation in human exposed to radiation.
کلیدواژه‌های انگلیسی مقاله Celecoxib,Genotoxicity,Ionizing radiation,Lymphocyte
نویسندگان مقاله سید جلال حسینی مهر | seyed jalal hosseinimehr
1department of radiopharmacy, faculty of pharmacy, pharmaceutical sciences research center, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

مهدیه فتحی | mahdieh fathi
1department of radiopharmacy, faculty of pharmacy, pharmaceutical sciences research center, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

آرش قاسمی | arash ghasemi
2department of radiology and radiation oncology, faculty of medicine, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

سیده نسا رضاییان شیاده | seyedeh nesa rezaeian shiadeh
1department of radiopharmacy, faculty of pharmacy, pharmaceutical sciences research center, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

طیب اله وردی پورفلاح | tayyeb allahverdi pourfallah
3department of biochemistry and biophysics, faculty of medicine, mazandaran university of medical sciences, sari, i.r. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مازندران (Mazandaran university of medical sciences)

نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/1747
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/115/article-115-350618.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communication
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