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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۲، صفحات ۱۱۵-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
چکیده انگلیسی مقاله Antimalarial drugs with the 4-aminoquinoline scaffold such as the important drugs, chloroquine (CQ) and amodiaquine (AQ), have been used to prevent and treat malaria for many years. The importance of these drugs is related to their simple usage, high efficacy, affordability, and cost-effectiveness of their synthesis. In recent years, with the spread of parasite resistance to CQ and cross-resistance to its other analogues have decreased their consumption in many geographical areas. On the other hand, AQ is an effective antimalarial drug which its usage has been restricted due to hepatic and hematological toxicities. The significance of the quinoline ring at quinoline-based antimalarial drugs has prompted research centers and pharmaceutical companies to focus on the design and synthesis of new analogues of these drugs, especially CQ and AQ analogues. Accordingly, various derivatives have been synthesized and evaluated in vitro and in vivo against the resistant strains of the malaria parasite to solve the problem of drug resistance. Also, the pharmacokinetic properties of these compounds have been evaluated to augment their efficacy and diminish their toxicity. Some of these analogues are currently in clinical and preclinical development. Consequently, the recent researches showed yet 4-aminoquinoline scaffold is active moiety in new compounds with antiplasmodial activity. Hence, the aim of this review article is to introduce of the novel synthetic analogues of CQ and AQ, which may constitute the next generation of antimalarial drugs with the 4-aminoquinoline scaffold. 
کلیدواژه‌های انگلیسی مقاله Malaria, Chloroquine, Amodiaquine, Drug Resistance
نویسندگان مقاله آرزو رفیعی پرهیزگار | arezoo rafiee parhizgar
malaria and vector research group mvrg , biotechnology research center brc , pasteur institute of iran, tehran, iran; and department of medicinal chemistry, pharmaceutical sciences branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

aazr تحقیقی | aazr tahghighi
malaria and vector research group mvrg , biotechnology research center brc , pasteur institute of iran, tehran, iran

سازمان اصلی تایید شده: انستیتو پاستور ایران (Pasteur institute of iran)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/2738
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-350676.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Article
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