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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۲، صفحات ۱۲۹-۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Comparing Adrenaline with Tranexamic Acid to Control Acute Endobronchial Bleeding: A Randomized Controlled Trial
چکیده انگلیسی مقاله Background: Hemoptysis occurs due to either pulmonary diseases or bronchoscopy interventions. The aim of the present study was to compare the efficacy of the endobronchial instillation of adrenaline with that of tranexamic acid. Methods: Fifty patients were randomly selected as 2 double-blinded sample groups (n=25). In these patients, bleeding could not be controlled with cold saline lavage during bronchoscopy and they, therefore, required prescription of another medicine. Adrenaline (1 mg) in one group and tranexamic acid (500 mg) in the other group were diluted in 20 mL of normal saline and instilled through the bronchoscope. This technique was repeated 3 times at 90-second intervals, if necessary. In the case of persistent bleeding, 90 seconds after the last dose, a second medicine was given for bleeding control. Observation of clot through the bronchoscope meant that the bleeding had stopped. The efficacy of tranexamic acid and adrenaline was evaluated and then compared using the Mann–Whitney test. Results: The time of bleeding control had no significant difference between tranexamic acid and adrenaline (P=0.908). Another analysis was done to evaluate bleeding control with a second medicine; the results showed that 1 (4%) patient in the tranexamic acid and 8 (32%) in the adrenaline group needed the second medicine and there was no significant difference between the 2 groups (P=0.609). Conclusion: Our results suggested that tranexamic acid by endobronchial instillation was as efficient as adrenaline in controlling hemoptysis and required less frequent use of a second medicine. Trial Registration Number: IRCT2014120220188
کلیدواژه‌های انگلیسی مقاله Epinephrine, Bronchoscopy, Hemoptysis, Tranexamic acid
نویسندگان مقاله میترا ثمره فکری | mitra samareh fekri
cardiovascular research center‚ institute of basic and clinical physiology sciences, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

سید مهدی هاشمی باجگانی | seyed mehdy hashemi bajgani
department of pulmonary‚ afzalipour hospital research center‚ kerman university of medical sciences‚ kerman‚ iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

احمد شفاهی | ahmad shafahi
department of pulmonary‚ afzalipour hospital research center‚ kerman university of medical sciences‚ kerman‚ iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

رزیتا زرشناس | rozita zarshenas
cardiovascular research center‚ institute of basic and clinical physiology sciences, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/1977
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-350677.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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