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Iranian Journal of Medical Sciences، جلد ۴۲، شماره ۲، صفحات ۲۱۵-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Renal Medullary Carcinoma; A Rare Entity
چکیده انگلیسی مقاله Abstract Renal medullary carcinoma (RMC) is an uncommon aggressive neoplasm of the kidney. RMC is biologically aggressive with a very poor prognosis, and metastasis is seen in up to 95% of the patients at diagnosis or shortly thereafter. The common sites of metastasis are respectively lymph nodes, lungs, livers, and adrenal glands in order of frequency. The presence of poorly differentiated eosinophilic cells in a characteristic fibro-inflammatory stroma is seen in histological examination. The origin and pathogenesis of RMC are unclear. The radiographical and pathological findings suggest that RMC probably originates in the calyceal epithelium in or near the renal papillae, which could be the result of chronic ischemic damage in the renal papillae epithelium by sickled erythrocytes. Positivity of VEGF and HIF-1α supports the chronic hypoxia that may be caused in the pathogenesis of RMC. Other factors such as genetic or environmental factors are important. Although hemoglobinopathy is very common, RMC is very rare. An understanding of the molecular and genetic factors of this rare disease is important for its prevention and treatment. We herein describe an adult Turkish patient, who presented with hematuria. The diagnosis was RMC after pathological examination.
کلیدواژه‌های انگلیسی مقاله Medullary carcinoma, Kidney neoplasms, Case reports
نویسندگان مقاله selahattin çalışkan | selahattin çalışkan
department of urology, çorum training and research hospital, hitit university, çorum,turkey


علی مرات gökçe | ali murat gökçe
department of surgery, haydarpaşa numune training and research hospital, istanbul ,turkey


gülistan gümrükçü | gülistan gümrükçü
department of pathology,haydarpaşa numune training and research hospital, istanbul,turkey


مینه önenerk | mine önenerk
department of pathology,haydarpaşa numune training and research hospital, istanbul,turkey
نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/1682
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-350689.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Case Report(s)
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