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Iranian Journal of Medical Sciences، جلد ۴۰، شماره ۳، صفحات ۲۴۸-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Resveratrol Supplementation on the SNARE Proteins Expression in Adipose Tissue of Stroptozotocin-Nicotinamide Induced Type 2 Diabetic Rats
چکیده انگلیسی مقاله Background: Glucose uptake by muscles and fat cells is carried out by the GLUT4 system. Isoforms of the SNAP23, syntaxin-4 and VAMP-2 play an important role in regulating GLUT-4 trafficking and fusion in adipocytes. The changes of SNARE proteins levels and thus impaired GLUT-4 displacement can be one of the etiological causes of type 2 diabetes. Due to changes in the expression of these proteins in diabetes, the aim of this study was to investigate the effect of the natural compound resveratrol with anti-diabetic properties on impaired expression of SNARE proteins in type 2 diabetes. Methods: Forty male Wistar rats were used in this study. Type 2 diabetes was induced by administering a single dose of streptozotocin and nicotinamide. The expression of SNAP-23, syntaxin-4 and VAMP-2 proteins were assessed using real-time qRT-PCR. Also, some biochemical parameters were examined, including fasting blood glucose, insulin levels and insulin resistance. Results: The results of this study showed that, resveratrol supplementation increased blood insulin level, reduced the fasting blood glucose, and improved the insulin resistance. In addition, resveratrol supplementation increased the expression of SNAP-23, syntaxin-4 and VAMP-2 proteins that involved in GLUT-4 transport in adipose tissue of diabetic rats. Conclusion: Final results showed that SNARE proteins expression is significantly reduced in diabetic rats and treatment with resveratrol supplementation is associated with the increased expression of these proteins.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله اعظم رضایی فریمانی | azam rezaei farimani
department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

مسعود سعیدی جم | massoud saidijam
research center for molecular medicine, hamadan university of medical sciences, hamadan iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

محمد تقی گودرزی | mohammad taghi goodarzi
research center for molecular medicine, hamadan university of medical sciences, hamadan iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

رضا یادگار آذری | reza yadegar azari
department of genetic and molecular medicine, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

سهیلا اسدی | soheila asadi
department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

صادق زارعی | sadegh zarei
department of biochemistry, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نوشین شباب | nooshin shabab
department of genetic and molecular medicine, school of medicine, hamadan university of medical sciences, hamadan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/692
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-350738.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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