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Iranian Journal of Psychiatry، جلد ۸، شماره ۲، صفحات ۷۳-۹
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عنوان انگلیسی Effects of zinc supplementation in patients with major depression: a randomized clinical trial.
چکیده انگلیسی مقاله Objective: Major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. Regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation in the treatment of this disease. Methods: This study was a double-blind randomized clinical trial. Forty four patients with major depression were randomly assigned to groups receiving zinc supplementation and placebo. Patients in Zinc group received daily supplementation with 25 mg zinc adjunct to antidepressant; Selective Serotonin Reuptake Inhibitors (SSRIs), while the patients in placebo group received placebo with antidepressants (SSRIs) for twelve weeks. Severity of depression was measured using the Beck Depression Inventory at baseline and was repeated at the sixth and twelfth weeks. ANOVA with repeated measure was used to compare and track the changes during the study . Results: The mean score of Beck test decreased significantly in the zinc supplemen group at the end of week 6 (P< 0.01) and 12 (P< 0.001) compared to the baseline. The mean score of Beck Depression Inventory reduced significantly compared to the placebo group at the end of 12th week (P< 0.05) Conclusion: The results of the present study indicate that zinc supplementation together with SSRIs antidepressant drug improves major depressive disorders more effectively in patients with placebo plus antidepressants (SSRIs).
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نویسندگان مقاله الهام رنجبر | elham ranjbar
faculty of nutrition sciences and food technology, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

معصومه ثابت کسایی | masoumeh sabet kasaei
department of pharmacology, neuroscience research center, faculty of medicine, shahid beheshti university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مینو محمد شیرازی | minoo mohammad shirazi
faculty of nutrition sciences and food technology, shahid beheshti university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

جواد نصرالله زاده | javad nasrollahzadeh
faculty of nutrition sciences and food technology, shahid beheshti university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

دکتر بهرام رشیدخانی | bahram rashidkhani
faculty of nutrition sciences and food technology, shahid beheshti university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شمس | jamal shams
department of psychiatry, imam hossein hospital, shahid beheshti university of medical science. tehran. iran

سازمان اصلی تایید شده: دانشگاه شهید بهشتی (Shahid beheshti university)

سید علی مصطفوی | seyed ali mostafavi
psychiatry and psychology research center- department of psychiatry, roozbeh hospital, tehran university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدی | mohammad reza mohammadi
psychiatry and psychology research center- department of psychiatry, roozbeh hospital, tehran university of medical sciences. tehran. iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/186
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