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Journal of Family and Reproductive Health، جلد ۱۰، شماره ۴، صفحات ۱۶۵-۱۷۵
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Role of Statin Drugs for Polycystic Ovary Syndrome
چکیده انگلیسی مقاله Objective: To review the potential role and specific impact of statin drugs in women with PCOS. The evidence for this use of statins in PCOS is limited and still under further investigation. Materials and methods: A search was conducted using PubMed, DynaMed and PubMedHealth databases through October 16, 2016 using the terms polycystic ovary syndrome, PCOS, hydroxymethylglutaryl-CoA reductase inhibitors, hydroxymethylglutaryl-CoA , statin, atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin. English-language trials evaluating statins in PCOS were obtained and incorporated if they provided relevant data for providers. Results: We summarize twelve trials involving statins in PCOS. The trials were predominantly 12 weeks to 3 months in length (8 of the 12 trials) and low to moderate dose of statin drugs were used. The majority (10 of 12) of the trials show that statins reduce testosterone levels or other androgen hormones (DHEA-S and androstenedione), half of the trials evaluating LH/FSH ratio show an improvement, and all had positive effects on lipid profiles. Conclusion: Statins show promising improvements in serum levels of androgens and LH/FSH ratios translating to improved cardiovascular risk factors above and beyond simply lowering LDL levels. More investigation is needed to determine if statins can clinically impact women with PCOS long term, particularly those who are young and are not yet candidates for traditional preventative treatment with a statin medication.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله lisa cassidy vu | lisa cassidy vu
department of family and community medicine, wake forest school of medicine, winston-salem, north carolina, united states


edwina joe | edwina joe
college of pharmacy and health sciences, campbell university, buies, creek


julienne k kirk | julienne k kirk
diabetes and endocrinology center, department of family and community medicine, wake forest school of medicine, winston-salem, north carolina, united states
نشانی اینترنتی http://jfrh.tums.ac.ir/index.php/jfrh/article/view/534
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/186/article-186-351050.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Review Articles
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