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Iranian Journal of Psychiatry، جلد ۷، شماره ۲، صفحات ۸۷-۹۲
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عنوان انگلیسی Melatonin effects in methylphenidate treated children with attention deficit hyperactivity disorder: a randomized double blind clinical trial.
چکیده انگلیسی مقاله The aim of this study was to determine melatonin effects on sleep patterns, symptoms of hyperactivity and attention deficiency in children with attention-deficit hyperactivity disorder (ADHD).Children with age range of 7-12 years who had a combined form of ADHD were randomly divided in to 2 groups according to gender blocks. One group took melatonin (3 or 6mg) combined with methylphenidate (Ritalin) (1mg/kg), and the other group took placebo combined with methylphenidate (1mg/kg). ADHD rating scale and sleep patterns questionnaires were completed. Research hypotheses were assessed at the baseline, the second, fourth and eighth weeks after the treatment.The mean sleep latency and total sleep disturbance scores were reduced in melatonin group, while the scores increased in the placebo group (p≥0.05). Data analysis, using ANOVA with repeated measures, did not show any statistically significant differences between the two groups in ADHD scores.Administration of melatonin along with methylphenidate can partially improve symptoms of sleep disturbance. However, it does not seem to reduce attention deficiency and hyperactivity behavior of children with ADHD.
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نویسندگان مقاله محمدی | mohammad reza mohammadi
psychiatry and psychology research center,tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید علی مصطفوی | seyed ali mostafavi


سید علی کشاورز | seyed ali keshavarz


محمد رضا اشراقیان | mohammad reza eshraghian


پیام حسین زاده | payam hosseinzadeh


محمد جواد حسین زاده عطار | mohammad javad hosseinzadeh attar


سید محمد علی کوشش | seyed mohammad ali kooshesh


مریم چمری | maryam chamari


شاهین آخوندزاده | shahin akhondzadeh


نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/207
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