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Journal of Biostatistics and Epidemiology، جلد ۲، شماره ۲، صفحات ۵۲-۵۹

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عنوان انگلیسی Cure mixture model based on hazard modeling non-proportional, application to esophageal cancer
چکیده انگلیسی مقاله Background & Aim: Esophageal cancer is one of the main common causes of death. The high prevalence of esophageal cancer in northern Iran is an important public health problem. The main aim of this paper was to assess the factors affecting survival of atients with esophageal cancer in neighbor provinces around the Caspian Sea using Weibull mixture cure model and mixture cure model based on a non-proportional hazard. Methods & Materials: This prospective study was designed to gather data of esophageal cancer from the Babol cancer registry, Iran, registered during 1990 to 1991. The study cases were also followed for a period of 15 years up to 2006. Mixture cure model via non-proportional hazard modeling was used to calculate cure fraction and investigate the factors responsible for the cure probability of patients. Estimates were obtained by maximization of the likelihood via SAS proc NLMIXED. Results: The median survival time was about 9 months and survival probability in 1, 3, and 5 years following diagnosis were 23%, 15% and 13%, respectively. The family history affected the cured fraction independently of its effect on the early outcome In addition, it had significant effect on the probability of uncured state in the both models. Conclusion: The results demonstrated the great potential in cure modeling survival data via nonproportional hazard model compared to Weibull mixture cure model.
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نویسندگان مقاله محبوبه رسولی | mahboubeh rasouli
department of biostatistics, public health school, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمودرضا قدیمی | mahmoodreza ghadimi
department of statistics, iranian social security organization, tehran, iran


معصومه شوهانی | masoomeh shohani
department of nursing, faculty of allied medical sciences, ilam university of medical sciences, ilam, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایلام (Ilam university of medical sciences)

آسیه عاشوری | asieh ashouri
guilan interventional cardiovascular research center, heshmat hospital, guilan university of medical sciences, rasht, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گیلان (Guilan university of medical sciences)

سمانه حسین زاده | samaneh hosseinzadeh
department of biostatistics, university of social welfare and rehabilitation sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم بهزیستی و توانبخشی (University of social welfare and rehabilitation sciences)

کاظم محمد | kazem mohammad
department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمود محمودی | mahmood mahmoodi
department of epidemiology and biostatistics, school of public health, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)


نشانی اینترنتی http://jbe.tums.ac.ir/index.php/jbe/article/view/78
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/362/article-362-351348.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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