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Journal of Arthropod-Borne Diseases، جلد ۱۸، شماره ۳، صفحات ۲۵۳-۲۶۳
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عنوان انگلیسی Leishmania spp Infection in Patients and Great Gerbils (Rhombomys opimus) in a High-Risk Focus of Zoonotic Cutaneous Leishmaniasis in Central Iran: a Microscopic and Molecular Survey
چکیده انگلیسی مقاله Background: Zoonotic cutaneous leishmaniasis (ZCL) is an endemic disease in Varzaneh City where Leishmania ma­jor is the causative agent and the great gerbil, Rhombomys opimus, is the main reservoir host of the disease. Despite control efforts, ZCL outbreaks recur every few years. This study was conducted to revive information on the parasite/s species circulating between humans and the reservoirs in the region. Methods: Leishmania infection in patients and R. opimus was studied using direct parasitological and molecular methods during 2019–2021. Nested-PCR and DNA sequencing were used for Leishmania parasite identification. Inter and intra-species variations in the Leishmania parasites were investigated using BLAST and MEGA7 software. Results: All suspected patients (N=34) and 14 out of 36 great gerbils tested positive for Leishmania parasites via direct parasitological method. Nested-PCR method revealed all the patients were infected with L. major (94.1%) and mixed infection of L. major and Leishmania turanica (5.9%), and great gerbil specimens were infected with either L. major (44.4%), L. turanica (5.6%), or Leishmania gerbilli (5.6%) and also with mixed infection of L. major and L. turanica (30.5%), L. major and L. gerbilli (8.3%) and mix of all the three Leishmania species (5.6%).   Conclusion: The identical sequences of L. major in both human patients and rodents indicate that the great gerbils are the main reservoirs of L. major in Varzaneh City. The presence of L. turanica in patients would be of interest to carry out further studies to determine the role of this species in the persistence, signs, and treatment of ZCL in humans.
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نویسندگان مقاله | Narges Marvi Moghadam
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mehdi Mohebali
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Yavar Rassi
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Ali Reza Zahraei-Ramazani
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Ali Oshaghi
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Reza Jafari
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mahboubeh Fatemi
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Mohammad Hossein Arandian
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Hamid Abdoli
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Nilufar Shareghi
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Maryam Ghanei
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Nilufar Jalali-Zand
Isfahan Health Research Station, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Arshad Veysi
Zoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Javad Ramazanpoor
Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Kurosh Aminian
Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Ali Salehi
Isfahan Health Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Ali Khamesipour
Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran


| Amir Ahmad Akhavan
Department of Vector Biology and Control of Diseases, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://jad.tums.ac.ir/index.php/jad/article/view/1656
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