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Iranian Journal of Pathology، جلد ۲۰، شماره ۲، صفحات ۱۴۲-۱۵۱
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عنوان انگلیسی The Value of the Galactomannan Test in Diagnosing COVID-19–Associated Pulmonary Aspergillosis: A Review
چکیده انگلیسی مقاله COVID–19–associated pulmonary aspergillosis (CAPA) is a complication of COVID-19. Galactomannan (GM) is a non-invasive test used to diagnose invasive aspergillosis. We collected the existing studies on the diagnostic value of GM to determine a GM level for predicting CAPA. All articles on the value of GM in CAPA diagnosis published until November 2023 were reviewed. The main databases were searched using the following keywords: “aspergillus”, “aspergillosis”, “SARS-CoV-2”, “COVID”, “2019 ncovnCOV”, “novel coronavirus”, “COVID-19”, “galactomannan”, and “CAPA”. Studies with reported levels of serum or BAL GM were included. Patients were classified into two groups: non-confirmed and proven aspergillosis. Finally, the receiver operating characteristic (ROC) curve analysis was used to determine a GM level to predict the likelihood of CAPA. A total of 26 articles were selected, of which 239 patients were included. A count of 123 patients (50%) were in the non-confirmed group and 124 (50%) patients were proven. The median serum GM was 0.51 in the non-confirmed group and 0.47 in the proven group (p= 0.73). The level of GM in BAL fluid was 0.10 in the non-confirmed and 2.80 in the proven group, which was statistically different (p<0.001). With 81.3 % sensitivity and 79.5% specificity, the BAL GM cut-off was 1.01 ODI. The results showed that BAL GM ≥1.01 can be used to predict CAPA. Serum GM did not show any predictive value in diagnosing CAPA. However, BAL GM level can be a reliable diagnostic test in patients with CAPA.
کلیدواژه‌های انگلیسی مقاله Galactomannan,Aspergillosis,SARS-CoV-2,COVID-19,Bronchoalveolar Lavage,fungi,Viral Diseases,Invasive fungal infections
نویسندگان مقاله Mohammadreza Salehi |
Research Center for Antibiotic Stewardship & Antimicrobial Resistance, Department of Infectious Diseases, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Jon Salmanton-García |
University of Cologne, Faculty of Medicine, and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany

Alireza Abdollahi |
Department of Pathology, School of Medicine, Imam Khomeini Hospital Complex, Tehran, Iran

Maryam Albaji |
Department of Pulmonary Diseases, Sina Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Effat Davoudi-Monfared |
Department of Clinical Pharmacy, Yas Hospital Complex, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Zeinab Siami |
Department of Infectious Diseases, School of Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran

Saeed Mohammadi |
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Sadegh Khodavaisy |
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Pershang Nazemi |
Department of Infectious Diseases, Yas Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_722790_70a050a4b967367d9a0337f6df81b75f.pdf
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