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Iranian Journal of Pathology، جلد ۲۰، شماره ۲، صفحات ۱۵۲-۱۵۸
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عنوان انگلیسی Prognostic Significance of lncRNA ATB and SNHG16 Expression Levels in Patients with Hepatocellular Carcinoma
چکیده انگلیسی مقاله Background & Objective: Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides, a major component of noncoding RNAs. Previous studies have shown the oncogenic role of various lncRNAs. This study aimed to explore the expression and prognostic value of ATB and SNHG16 in patients with hepatocellular carcinoma.
Methods: ATB and SNHG16 expression in tumor and adjacent normal tissues was identified using real-time quantitative PCR. In this study, patients were divided into 2 groups based on the expression level of each gene, and the correlation between expression level and clinicopathological features of patients with HCC was investigated. All data were analyzed using SPSS version 22.
Results: Of the lncRNAs examined in this study, ATB was expressed at significantly higher levels in tumor tissues. However, this overexpression was not associated with any clinicopathological features of HCC patients.
Conclusion: In this study, overexpression of ATB and SNHG16 was not associated with survival rate or clinicopathological features of patients with hepatocellular carcinoma.
کلیدواژه‌های انگلیسی مقاله Hepatocellular Carcinoma,Long Noncoding RNAs,Tumor
نویسندگان مقاله Sahar Ravanshad |
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammadhossein Taherynejad |
Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Zohre Gerami |
Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Amin Dalili |
Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Ayatollahi |
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Hassan Mehrad-Majd |
Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی https://ijp.iranpath.org/article_722789_b47d9092f4ad4487ebed68756f56d1ac.pdf
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