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Iranian Journal of Pathology، جلد ۲۰، شماره ۲، صفحات ۲۰۰-۲۰۷
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عنوان انگلیسی IL-8/CD181 Mediated Inflammation in SLE-Associated Hemolytic Anemia
چکیده انگلیسی مقاله Background & Objective: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by immune dysregulation, autoantibody production, and organ damage, notably in the kidneys. Cytokine imbalances contribute to SLE's diverse clinical presentations. This study investigated the roles of interleukin-8 (IL-8) and its receptor, CD181 (CXCR1), in SLE pathogenesis, specifically focusing on their association with hemolytic anemia, a severe complication.
Methods: This research investigates the role of interleukin-8 (IL-8) and its cognate receptor, CXCR1 (CD181). It was analyzed clinical and demographic data from 250 SLE patients and quantified IL-8 and CD181 mRNA and protein expression in samples from patients with active SLE, inactive SLE, and SLE complicated by hemolytic anemia, comparing them to healthy controls.
Results: Of the 250 samples, 84% were from SLE patients, with 67% in the active disease phase. Significant upregulation of both IL-8 and CD181 mRNA and protein was observed in SLE patients compared to controls. Specifically, mRNA expression was significantly elevated in active SLE (p=0.0001) and inactive SLE (p=0.01). Notably, IL-8 mRNA expression was significantly higher in SLE patients with hemolytic anemia (p<0.0001) compared to those without (p<0.01(.
Conclusion: These findings suggest that the IL-8/CD181 axis plays a crucial role in the inflammatory processes and tissue damage associated with SLE, particularly in the development of hemolytic anemia.
کلیدواژه‌های انگلیسی مقاله SLE,IL-8,CD181,CXCR1,hemolytic anemia and mRNA
نویسندگان مقاله Muslim I Mohsin |
University of Kufa, Faculty of Science, Pathological Laboratory Analysis Department, Najaf, Iraq

Samer I Al-Hilali |
University of Kufa, Faculty of Science, Pathological Laboratory Analysis Department, Najaf, Iraq

Rusul Idan Mohsin |
Jabir Ibn Hayyan University for Medical and Pharmaceutical Sciences, Najaf, Iraq

Mohammed I Mohasin |
University Of Dhaka, Department of Biochemistry and Molecular Biology, Dhaka, Bangladesh

Mohammed Jasim Mohammed Al-Shamarti |
University of Kufa, Faculty of Science, Pathological Laboratory Analysis Department, Najaf, Iraq

نشانی اینترنتی https://ijp.iranpath.org/article_722680_3646f2fdc4f4cfedb019325b7c8e9ea0.pdf
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