این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
گوارش، جلد ۱، شماره ۱، صفحات ۳۰-۳۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of Hairy and Enhancer of Split(HES-1) Expression in Different Types of Colorectal Polyps
چکیده انگلیسی مقاله Background: Colorectal cancer (CRC) is considered to be the fourth leading cause of cancer death worldwide. Objectives: This study aimed to investigate the Hairy and Enhancer of Split-1 (HES-1) expression in different types of colorectal polyps. Materials and Methods: In this analytical study, we included 100 patients with colorectal polyps who were referred to Tehran, Iran. HES-1 immunostaining was performed to evaluate nuclear and/or cytoplasmic staining for HES-1 in the specimens. Then, the data were analyzed in terms of age, sex, side location, and polyp type. Results:   Out of 100 subjects, 62 were men and 38 were women. The highest prevalence of polyps was observed in the rectum (34%), and the most common type of polyp was tubular adenoma (40%). HES-1 index was only positive in 22 cases. There was a significant relationship between HES-1 positivity and both polyp location (P<0.001), polyp type (P<0.001), and grade of dysplasia (P=0.019). However, there was no significant relationship between HES-1 positivity and adenomatous polyp type (P=0.52). The distribution of HES-1 positivity on the left side was significantly higher, and the relationship between HES-1 positivity and side location was significant (P=0.002). Conclusion: This study suggests that HES-1 can be useful in differentiating SSA/P and HP with high sensitivity and specificity.
کلیدواژه‌های انگلیسی مقاله Polyp,Colon,Pathology,Immunohistochemistry markers,HES-1
نویسندگان مقاله | Behrang Kazeminezhad
Pathologist, Golestan University of Medical Sciences, Gorgan, Iran


| Nina Mahvidi Zadeh
Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Melika Ghandehari
Assistant Professor of Pathology, Department of Pathology, School of Medicine, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Tahmineh Mollasharifi
Associate Professor of Pathology, Department of Pathology, School of Medicine, Men’s Health and Reproductive Health Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Afshin Moradi
Assistant Professor of Molecular Pathology & Cytogenetics, Department of Pathology, School of Medicine, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Atoosa Gharib


نشانی اینترنتی http://govaresh.org/index.php/dd/article/view/2717
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات