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Middle East Journal of Digestive Diseases، جلد ۱۷، شماره ۲، صفحات ۱۲۸-۱۳۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chromogranin A as a Novel Biomarker of Irritable Bowel Syndrome in Adults: A Systematic Review and Meta-Analysis
چکیده انگلیسی مقاله Background: Irritable bowel syndrome (IBS) is a chronic condition characterized by recurring abdominal discomfort and irregular bowel movements. Currently, IBS diagnosis lacks specific radiological, biochemical, or endoscopic markers. Chromogranin A (CgA), a gastrointestinal protein, shows variation between IBS patients and healthy controls. This study aims to evaluate differences in CgA concentrations between these groups. Methods: This review was conducted in 2023 using the PRISMA 2020 guidelines. All observational research were retrieved from MEDLINE, EBSCO-Host, ScienceDirect, and ProQuest electronic databases using a predefined search strategy. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) and meta-analysis was conducted using Review Manager (RevMan) 5.4. Results : Nine out of fourteen studies eligible for meta-analysis, revealing significantly higher CgA cell density (p=0.0001) in all IBS patients compared to controls. This difference persisted across colon regions (left: p=0.04, right: p=0.0009) and duodenum (p<0.00001). Notably, subgroup analysis found no significant disparity in CgA cell density between diarrhea and constipation- predominant IBS within duodenum or colon. Conclusion: CgA cell density showed trends toward IBS compared to control groups, with significant concentration differences were found in the duodenum, left, and right colon. Therefore, current findings might offer a histopathological approach to confirm the IBS diagnosis.
کلیدواژه‌های انگلیسی مقاله Irritable Bowel Syndrome, Chromogranin A, gaster, duodenum, colon
نویسندگان مقاله | Virly Nanda Muzellina
Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia


| Nicolas Daniel Widjanarko
Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia


| Jonathan Christianto Subagya
Faculty of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia


| Steven Alvianto


نشانی اینترنتی http://mejdd.org/index.php/mejdd/article/view/3146
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.15171/middle east j di.v17i2.3146
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Systematic Review
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