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International Journal of Radiation Research، جلد ۲۳، شماره ۲، صفحات ۲۷۷-۲۸۱
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عنوان انگلیسی Relationship between tumor parameters in Ga-68 PSMA PET/CT and pathological grade grouping in patients with prostate cancer
چکیده انگلیسی مقاله
Background: The study aims to explore the relationship between tumor parameters acquired from Ga-68 PSMA PET/CT and GG system in patients who had prostate cancer. Materials and Methods: One hundred and fourteen patients diagnosed with prostate cancer and who underwent Ga-68 PSMA PET/CT imaging for staging purposes were enrolled. The imaging was performed using a Siemens Biograph Horizon-3R 16 slice PET/CT device, and the tumor parameters (SUVmax, SUVmean, and Tumor volume) were calculated by an experienced nuclear medicine physician. Results: There was a correlation between GG with SUVmax (p:0.010; r:0.241) and SUVmean (p:0.06; r:0.258). In redicting high-risk patients, ROC analysis was conducted for SUVmax and SUVmean, resulting in significant cut-off values for both parameters. A cut-off value of 9.8 for SUVmax resulted in a sensitivity of 69% and a specificity of 58%. 5.8 cut-off value for SUVmean resulted in 68% sensitivity  and 58% specificity. Tumor volume was found to be a significant predictor for distant metastasis. When a cut-off value of 11.53 cm3 was used for tumor volume, sensitivity was found to be 62% and specificity 56%. Conclusion: According to the results, correlation between GG with SUVmax and SUVmax was significant. Additionally, SUVmax and SUVmean were significant predictors of high-risk prostate cancer, while TV was a significant predictor of distant metastases. In summary, Ga-68-PSMA PET CT are deemed a beneficial imaging modality for both prognosis assessment and staging in clinical.
کلیدواژه‌های انگلیسی مقاله Ga-68 PSMA PET/CT, prostate cancer, pathological grade grouping.
نویسندگان مقاله | F. Demir
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| S. Karaçavuş
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| H. Gençer
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| A. Özdal
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| Z. Erdoğan
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| İ. Çiftçi
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| F. Çevik Kaya
Department of Pathology, Kayseri Training and Research Hospital, Kayseri, Turkey


| N. Özhan
Department of Oncology, Kayseri Training and Research Hospital, Kayseri, Turkey


| H. İşçi
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey


| M. Kaya
Department of Nuclear Medicine, Kayseri Training and Research Hospital, Kayseri, Turkey
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1325&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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