| چکیده انگلیسی مقاله |
Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and other ncRNA types, have emerged as key regulators in neurodegenerative diseases and brain tumors. This review aims to provide insights into the role of ncRNAs in these conditions and their potential as diagnostic and therapeutic targets. We systematically reviewed literature from databases such as PubMed, Scopus, and Web of Science, applying specific inclusion and exclusion criteria to ensure comprehensive coverage of recent advancements. Although ncRNAs are involved in a range of molecular pathways, challenges in clinical translation, including specificity, cost, and validation, persist. This review highlights innovative strategies to overcome these barriers and promote the clinical application of ncRNAs. Moreover, we explore the emerging role of extracellular vesicle-enriched ncRNAs as cell-free therapeutic options for neurodegenerative diseases. The findings presented here emphasize the need for robust validation and the development of specific ncRNA-based treatments. |
| کلیدواژههای انگلیسی مقاله |
Alzheimer’s disease, brain cancer, Extracellular vesicles Glioma, Long non-coding RNA, MicroRNA Neurodegenerative diseases, Non-coding RNA |
| نویسندگان مقاله |
| Mohamed Javad Saadh
Faculty of Pharmacy, Middle East University, Amman, 11831, Jordan
| Sarraa Ahmad Qahtan
Department of Anesthesia Techniques, Health and Medical Techniques College, Alnoor University, Mosul, Iraq
| Rafid Jihad Albadr
Ahl al Bayt University, Karbala, Iraq
| Gaurav Sanghvi
Marwadi University Research Center, Department of Microbiology, Faculty of Science, Marwadi University, Rajkot-360003, Gujarat, India
| Rangaswamy Roopashree
Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
| Aditya Kashyap
Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India
| A. Sabarivani
Department of Biomedical, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India
| Jasur Rizaev
Department of Public Health and Healthcare Management, Rector, Samarkand State Medical University, 18, Amir Temur Street, Samarkand, Uzbekistan
| Waam Mohammed Taher
College of Nursing, National University of Science and Technology, Dhi Qar, Iraq
| Mariem Alwan
Pharmacy college, Al-Farahidi University, Iraq
| Mahmod Jasem Jawad
Department of Pharmacy, Al-Zahrawi University College, Karbala, Iraq
| Ali M. Ali Al-Nuaimi
Gilgamesh Ahliya University, Baghdad, Iraq
|