این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۸، صفحات ۱۰۰۴-۱۰۱۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Inhibition of HDAC3 induces neuroprotection by activating the Npas4 signaling pathway following surgical brain injury in rats
چکیده انگلیسی مقاله Objective(s): Histone deacetylase 3 (HDAC3) can acetylate histones, negatively regulating Neuronal Per-Arnt-Sim domain protein 4 (Npas4) and participating in various pathological processes of central nervous system lesions. However, the role of HDAC3 in early surgical brain injury (SBI) remains elusive. This study aimed to determine the role of HDAC3 in early rat SBI and its underlying mechanism.Materials and Methods: The SBI model was constructed using the right frontal lobotomy of adult male Sprague-Dawley rats. The effects of RGFP966, a specific HDAC3 inhibitor, were assessed by western blotting, immunofluorescence, neurological scoring, and fluoro-Jade C staining.Results: HDAC3 protein expression was up-regulated after SBI and peaked at 24 hr relative to the Sham group. RGFP966 application can significantly improve brain edema and neurological dysfunction 24 hr after SBI, enhance autophagy, and reduce inflammation. In addition, we observed that Npas4 expression increased in SBI rats and was further up-regulated after HDAC3 inhibition.Conclusion: HDAC3 plays a role in rats’ complex pathogenesis of SBI. HDAC3 inhibition imparts a protective role in early brain injury in SBI in rats by regulating autophagy and inflammation via up-regulation of Npas4.
کلیدواژه‌های انگلیسی مقاله Autophagy, Brain injury, HDAC3, Inflammation, Npas4
نویسندگان مقاله | Haiping Gu
Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Yating Gong
Department of Rehabilitation, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Muyao Wu
Department of Rehabilitation, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Mengying Shi
Department of Anesthesiology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Jiejie Yu
Department of Emergency, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Hongfei Zhu
Department of Orthopaedics, The Affiliated Aoyang Hospital of Jiangsu University, Suzhou, China


| Ya-ming Sun
Department of Neurology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China


| Baoqi Dang
Department of Rehabilitation, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25891.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات