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Iranian Journal of Psychiatry، جلد ۲، شماره ۲، صفحات ۵۸-۶۴
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عنوان انگلیسی The Efficacy and Safety of Add-on Ginko TD (Ginkgo Biloba) Treatment for PTSD: Results of a 12-Week Double-Blind Placebo-Controlled Study
چکیده انگلیسی مقاله Objective: Exposure to traumatic stressors lead to activation of arousal responses mediated by serotonergic and noradrenergic systems and it may cause a change in numerous neurotransmitters and neuroendocrine systems. There is ample experimental and clinical evidence to suggest that Ginkgo biloba extract is neuroprotective and has antioxidant properties and can restore stress-induced elevation in brain levels of catecholamines, 5-HT and plasma corticosterone to normal level. Method: In a 12-week, double-blind, placebo-controlled study, the efficacy and safety of adding-on a fixed-dose (200mg) of Ginkgo TD to the previous treatment regime of adults with PTSD were examined. Subjects were forty male and female outpatients from a public-owned psychiatric clinic who met criteria for PTSD seven month after a 6.3 Richter earthquake in Bam city on December 26, 2003. The changes in five symptom domains including posttraumatic stress, anxiety and affective symptoms, general health and subjective stress after trauma were ssessed at weeks 0, 12 and 16 to examine effectiveness of the added-on Ginkgo TD and stability of its effects. Results: Ginkgo TD was associated with a significantly greater improvement than placebo in PTSD patients as measured by five symptom domain scales including: GHQ-28; Watson PTSD Scale; HAM-D; HAM-A and IES (p= 0.02, 0.01, 0.001, 0.01, 0.02 respectively) Four weeks after the discontinuation of intervention, no significant difference was determined between the two groups in the five outcome measures (p= 0.005, 0.01, 0.004, 0.005, 0.01 respectively). No significant difference was observed between the two groups in terms of side effects. Conclusions: We found Ginkgo TD to be superior to placebo as an adding-on in the treatment of PTSD. Although we did not examine the comparative efficacy of Ginkgo TD on the three main elements of PTSD, beneficial effects both on specific PTSD symptomatology and general conditions including anxiety, depression, general health and perceived stress were indicated.
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نویسندگان مقاله لاله کوهی حبیبی | laleh koohi habibi
tehran psychiatry institute, tehran, iran


بهزاد قربانی | behzad ghorbani
iranian neuroscience research network


علیرضا نوروزی | ali reza norouzi
senior officer of substance abuse prevention and treatment office, bureau of psychosocial health, deputy for health, ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

شارخ s p گودرزی | sharokh s p gudarzi
department of psychiatry, shaheed beheshtiti university of medical science, tehran, iran


شمس | jamal shams
neuroscience research center, shaheed beheshtiti university of medical science, tehran, iran department of psychiatry, shaheed beheshtiti university of medical science, tehran, iran ave sina research institute, acecr, tehran, iran


محمد تقی یاسمی | mohammad taghi yasami
department of psychiatry, shaheed beheshtiti university of medical science, tehran, iran
نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/438
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