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Iranian Journal of Psychiatry، جلد ۱، شماره ۲، صفحات ۵۴-۵۸
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عنوان انگلیسی Combination of Citalopram and Nortriptyline in the Treatment of Obsessive-Compulsive Disorder: A Double – Blind, Placebo-Controlled Trial
چکیده انگلیسی مقاله Objective: The fact that some antidepressants with strong effects on serotonin reuptake blockade fail to relieve obsessive-compulsive symptoms has caused growing interest in investigating noradrenergic function in obsessive-compulsive disorder (OCD) . In light of the above, we undertook a trial to investigate whether the combination of citalopram with nortriptyline is more effective in treating obsessive-compulsive symptoms than citalopram alone. Method: 40 patients who met the DSM-IV criteria for OCD were included in the study. Patients were allocated in a random fashion: 20 patients to citalopram 40mg /day plus nortriptyline 50mg /day, and 20 patients to citalopram 40mg /day plus placebo. Results: Both protocols significantly decreased the scores of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) over the trial period, but the combination of citalopram and nortriptyline showed a significant superiority over citalopram alone in the treatment of OCD. Conclusion: As this study indicates, nortriptyline improves the efficacy of citalopram. In addition, a rapid onset of action is one of the advantages of this combination. This study supports further investigation of the noradrenergic– serotonergic hypothesis in OCD.
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نویسندگان مقاله فیروزه رییسی | firoozeh raisi
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran department of psychiatry, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مرضیه توکلی | marzieh tavakoli
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباس علی ناصحی | abbas ali nasehi
iran helal institute of applied science amp;amp;technology
نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/405
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