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Iranian Journal of Psychiatry، جلد ۱، شماره ۱، صفحات ۳۹-۴۱
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عنوان انگلیسی Comparing the Effects of Clomipramine and Fluoxetine on Fasting Blood Glucose in Children With Obsessive-Compulsive Disorder
چکیده انگلیسی مقاله Objective: This study was conducted to compare the effects of clomipramine and fluoxetine on fasting blood glucose (FBS) in children with obsessive-compulsive disorder (OCD). Method: Thirty nondiabetic children with OCD entered this randomized trial. Subjects were between 7 to 17 years of age and had not received any medication that could affect blood glucose level for at least 2 weeks prior to the initiation of the study. Patients were assigned to receive 20 to 60 mg/d of fluoxetine or 75 to 200 mg/d of clomipramine for 8 weeks. The exclusion criteria were pregnancy and lactation, history of diabetes mellitus, any liver and thyroid disorder, epilepsy and major heart disease. Additionally, none of the patients should have received electroconvulsive therapy within 6 months prior to the initiation of the study. FBS levels were measured at baseline, 4 and 8 weeks after the initiation of the trial. Results: In the fluoxetine group, FBS level was decreased from 82.93 mg/dL (baseline) to 79.73 mg/dL at week 4 (P< 0.001) and to 72.53 mg/dL at week 8 (P< 0.001). On the other hand, in the clomipramine group, FBS level was increased from 84.93 mg/dL (baseline) to 87.00 mg/dL at week 4 (P< 0.05) and to 95.33 mg/dL at week 8 (P< 0.001). Conclusion: This 8-week study demonstrated that FBS levels may decrease in children with OCD who received flouxetine, and may increase in those treated with clomipramine. Therefore, it is suggested that FBS levels should be monitored and taken into consideration when choosing between fluoxetine and clomipramine in the treatment of OCD.
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نویسندگان مقاله رضا ترک زبان | reza torkzaban
school of pharmacy, tehran university of medical sciences

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمدرضا محمدی | mohammadreza mohammadi
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran department of psychiatry, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

پدیده قایلی | padideh ghaeli
psychiatry and psychology research center, roozbeh hospital, tehran university of medical sciences, tehran, iran department of psychiatry, roozbeh hospital, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرشاد هاشمیان | farshad hashemian
school of pharmacy, azad university tehran
نشانی اینترنتی http://ijps.tums.ac.ir/index.php/ijps/article/view/402
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